TUMOR SUPPRESSOR GENE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does tumor suppressor gene mean? 

• TUMOR SUPPRESSOR GENE (noun)
  The noun TUMOR SUPPRESSOR GENE has 1 sense:

1. a suppressor gene that blocks unscheduled cell division

  Familiarity information: TUMOR SUPPRESSOR GENE used as a noun is very rare.

 Dictionary entry details 

• TUMOR SUPPRESSOR GENE (noun)

Sense 1

Meaning:

A suppressor gene that blocks unscheduled cell division

Classified under:

Nouns denoting body parts

Hypernyms ("tumor suppressor gene" is a kind of...):

suppresser; suppresser gene; suppressor; suppressor gene (a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene))

 Context examples 

Antineoplaston A10 may also inhibit ras-oncogene expression and activate tumor suppressor gene p53, leading to cell differentiation and apoptosis.

(Antineoplaston A10, NCI Thesaurus)

Hsp70 plays a significant role in protein unfolding for entry into mitochondria and also interacts with tumor suppressor gene products to produce their anti-proliferative activity.

(Interferon Signaling Modulation Pathway, NCI Thesaurus/BIOCARTA)

The gene encoding this protein is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV).

(JAW1-Related Protein, NCI Thesaurus)

In addition, antineoplastons may inhibit RAS oncogene expression and activate the tumor suppressor gene p53, resulting in cell differentiation and apoptosis.

(Antineoplaston Agent, NCI Thesaurus)

An autosomal dominant hereditary neoplastic syndrome caused by an alteration in the p53 tumor suppressor gene.

(Li-Fraumeni syndrome, NCI Thesaurus)

An autosomal dominant disorder caused by mutations in the NF2 tumor suppressor gene.

(Neurofibromatosis type 2, NCI Thesaurus)

Once in a cell, Granzyme A activates DNA nicking by the recently identified DNAse NM23-H1, a tumor suppressor gene product whose expression is reduced in transformed, metastatic cells.

(Granzyme A Mediated Apoptosis Pathway, NCI Thesaurus/BIOCARTA)

In addition, this gene is a candidate tumor suppressor gene for human breast cancer.

(FABP3 Gene, NCI Thesaurus)

In particular, this agent enhances the histone acetylation of the tumor suppressor gene p53.

(HDAC inhibitor CG200745, NCI Thesaurus)

Multiple endocrine neoplasia caused by inactivation of the tumor suppressor gene MEN-1.

(Multiple Endocrine Neoplasia Type 1, NCI Thesaurus)