TRANSGENE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does transgene mean? 

• TRANSGENE (noun)
  The noun TRANSGENE has 1 sense:

1. an exogenous gene introduced into the genome of another organism

  Familiarity information: TRANSGENE used as a noun is very rare.

 Dictionary entry details 

• TRANSGENE (noun)

Sense 1

Meaning:

An exogenous gene introduced into the genome of another organism

Classified under:

Nouns denoting body parts

Hypernyms ("transgene" is a kind of...):

cistron; factor; gene ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity)

 Context examples 

After intratumoral injection and adenovector-mediated gene transfer of MDA7 into tumor cells, the expressed MDA7 transgene may inhibit tumor cell proliferation and induce tumor cell apoptosis.

(Adenovector Encoding MDA7, NCI Thesaurus)

Belagenpumatucel-L is prepared by transfecting allogeneic non-small cell lung cancer (NSCLC) cells with a plasmid containing a TGF-beta2 antisense transgene, expanding the cells, and then irradiating and freezing them.

(Belagenpumatucel-L, NCI Thesaurus)

In addition, rRp450 expresses the cytochrome P450 transgene that activates oxazaphosphorines, such as cyclophosphamide (CPA).

(Oncolytic HSV-1 rRp450, NCI Thesaurus)

Included in proliferative disorders as stomal abnormalities seen thus far are more likely a consequence of transgene construct.

(Fibrosis NOS of the Mouse Prostate Gland, NCI Thesaurus/MMHCC)

A cancer vaccine comprised of a recombinant vaccinia viral vector encoding the carcinoembryonic antigen (CEA), MUC-1 (mucin-1), a transmembrane glycoprotein secreted by glandular tissues, and TRICOM, comprised of the three co-stimulatory molecule transgenes B7-1, ICAM-1 and LFA-3.

(Inalimarev, NCI Thesaurus)

These allogeneic Ad-specific CTLs are prepared by multiple rounds of stimulation with donor peripheral blood mononuclear cells and lymphoblastoid cell lines that have been transduced with Ad5f35, a recombinant adenoviral vector carrying no transgene.

(Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes, NCI Thesaurus)

A cancer vaccine comprised of a recombinant fowlpox viral vector encoding the carcinoembryonic antigen (CEA), MUC-1, a transmembrane glycoprotein secreted by glandular epithelial tissues, and TRICOM, comprised of three co-stimulatory molecule transgenes (B7-1, ICAM-1 and LFA-3).

(Falimarev, NCI Thesaurus)

Upon administration, this agent may elicit a cytotoxic T lymphocyte (CTL) response against host NSCLC cells, resulting in decreased tumor cell proliferation; vaccine immunogenicity may be potentiated by suppression of tumor TGF-beta2 production by antisense RNA expressed by the vaccine plasmid TGF-beta2 antisense transgene.

(Belagenpumatucel-L, NCI Thesaurus)