MITOMYCIN

Pronunciation (US):

(GB):

 Dictionary entry overview: What does mitomycin mean? 

• MITOMYCIN (noun)
  The noun MITOMYCIN has 1 sense:

1. a complex of antibiotic substances obtained from a streptomyces bacterium; one form (trade name Mutamycin) shows promise as an anticancer drug

  Familiarity information: MITOMYCIN used as a noun is very rare.

 Dictionary entry details 

• MITOMYCIN (noun)

Sense 1

Meaning:

A complex of antibiotic substances obtained from a streptomyces bacterium; one form (trade name Mutamycin) shows promise as an anticancer drug

Classified under:

Nouns denoting man-made objects

Synonyms:

mitomycin; Mutamycin

Hypernyms ("mitomycin" is a kind of...):

antibiotic; antibiotic drug (a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections)

 Context examples 

Bioreduced mitomycin B generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis.

(Mitomycin B, NCI Thesaurus)

Also called mitomycin C and Mutamycin.

(Mitozytrex, NCI Dictionary)

Bioreductively activated mitomycin antibiotics generate oxygen radicals and alkylate DNA, forming inter-strand cross-links and inhibiting DNA synthesis.

(Mitomycin Antineoplastic Antibiotic, NCI Thesaurus)

Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations.

(Mitomycin, NCI Thesaurus)

An indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities.

(Apaziquone, NCI Thesaurus)

Also called mitomycin C and Mitozytrex.

(Mutamycin, NCI Dictionary)

Mitomycin C alkylates DNA, producing DNA cross-links and inhibiting DNA replication.

(Folate Receptor-Targeted Vinca Alkaloid/Mitomycin C EC0225, NCI Thesaurus)

A regimen consisting of cisplatin, mitomycin and vinblastine used to treat advanced-stage non-small cell lung cancer.

(Cisplatin-Mitomycin-Vinblastine Regimen, NCI Thesaurus)

A regimen consisting of fluorouracil, doxorubicin and mitomycin used for the treatment of advanced-stage gastric and pancreatic cancer.

(FAM Regimen, NCI Thesaurus)

A pegylated liposomal formulation comprised of a lipophilic prodrug of the antineoplastic antibiotic mitomycin C containing a cleavable disulfide bond (PL-MLP), with potential antineoplastic activity.

(Pegylated Liposomal Mitomycin C Lipid-based Prodrug, NCI Thesaurus)