EXOTOXIN

Pronunciation (US):

(GB):

 Dictionary entry overview: What does exotoxin mean? 

• EXOTOXIN (noun)
  The noun EXOTOXIN has 1 sense:

1. a toxin that is secreted by microorganisms into the surrounding medium

  Familiarity information: EXOTOXIN used as a noun is very rare.

 Dictionary entry details 

• EXOTOXIN (noun)

Sense 1

Meaning:

A toxin that is secreted by microorganisms into the surrounding medium

Classified under:

Nouns denoting substances

Hypernyms ("exotoxin" is a kind of...):

toxin (a poisonous substance produced during the metabolism and growth of certain microorganisms and some higher plant and animal species)

Antonym:

endotoxin (a toxin that is confined inside the microorganisms and is released only when the microorganisms are broken down or die)

 Context examples 

ERB-38 immunotoxin binds specifically to cells that overexpress HER2, the antigenic target of the monoclonal antibody; the exotoxin portion of the immunotoxin then lyses the cells bound by the antibody portion.

(Erb-38 immunotoxin, NCI Thesaurus)

This species is aerotolerant, non-exotoxin producing, ferments glucose, lactose, maltose and sucrose, reduces nitrate and is nonproteolytic.

(Clostridium tertium, NCI Thesaurus)

This species is sporeforming, hemolytic, produces exotoxins and is lecithinase, lipase, indole and urease negative.

(Clostridium septicum, NCI Thesaurus)

This species is indole negative, produces a weak exotoxin and is positive for nitrite reaction.

(Clostridium fallax, NCI Thesaurus)

An immunotoxin consisting of an anti-CD40 antibody linked to a 40kD fragment of Pseudomonas exotoxin.

(G28-5 sFv-PE40, NCI Thesaurus)

A fusion protein consisting of the cytokine interleukin-4 (IL-4) linked to a truncated form of Pseudomonas exotoxin with potential antineoplastic activity.

(IL4-Pseudomonas Exotoxin Fusion Protein PRX321, NCI Thesaurus)

The antibody attaches to the tumor cell and the exotoxin stops protein synthesis by inactivating elongation factor 2.

(LMB-1 immunotoxin, NCI Thesaurus)

A fusion protein consisting of the Fv portion of a monoclonal antibody attached to a 38-kDa fragment of the Pseudomonas exotoxin A (with amino acids 365-380 deleted).

(LMB-2 immunotoxin, NCI Thesaurus)

The antibody attaches to the cell and the exotoxin inhibits protein synthesis by inactivating elongation factor 2.

(LMB-7 immunotoxin, NCI Thesaurus)

A recombinant disulfide stabilized anti-Lewis Y IgG immunotoxin containing a 38 KD toxic element derived from the Pseudomonas aeruginosa exotoxin A and a monoclonal antibody fragment, designed to target adenocarcinomas expressing Lewis Y.

(LMB-9 immunotoxin, NCI Thesaurus)