EFFLUX

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does efflux mean? 

• EFFLUX (noun)
  The noun EFFLUX has 1 sense:

1. the process of flowing out

  Familiarity information: EFFLUX used as a noun is very rare.

 Dictionary entry details 

• EFFLUX (noun)

Sense 1

Meaning:

The process of flowing out

Classified under:

Nouns denoting natural processes

Synonyms:

effluence; efflux; outflow

Hypernyms ("efflux" is a kind of...):

flow (any uninterrupted stream or discharge)

Antonym:

influx (the process of flowing in)

 Context examples 

This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.

(Felodipine, NCI Thesaurus)

Phenytoin exerts its effect most likely through an enhancement of sodium efflux from neurons in the motor cortex.

(Fosphenytoin Sodium, NCI Thesaurus)

An orally bioavailable combination tablet containing the semisynthetic camptothecin derivative irinotecan and the multidrug resistance (MDR) efflux pump P-glycoprotein (P-gp) inhibitor HM30181AK, with potential antineoplastic activity.

(Irinotecan/P-glycoprotein Inhibitor HM30181AK Combination Tablet, NCI Thesaurus)

This protein is involved in mediating nucleoside influx and efflux.

(Equilibrative Nucleoside Transporter 1, NCI Thesaurus)

In addition, epothilone KOS-1584 is a poor substrate for the P-glycoprotein (P-gp) drug efflux pump.

(Epothilone KOS-1584, NCI Thesaurus)

Dofequidar fumarate, like many other MDR reversal agents, binds competitively to the drug-binding site of the transmembrane P-glycoprotein efflux pump (P-gp).

(Dofequidar Fumarate, NCI Thesaurus)

This gene is involved in drug efflux.

(ABCC2 Gene, NCI Thesaurus)

In addition, TAK-285 appears to pass the blood brain barrier (BBB) and does not appear to be a substrate for efflux pumps.

(EGFR/HER2 Kinase Inhibitor TAK-285, NCI Thesaurus)

Although the mechanism of action is not well established, mephenytoin potentially promotes sodium efflux from neurons in motor cortex, and stabilizes the threshold against hyperexcitability caused by excessive stimulation.

(Mephenytoin, NCI Thesaurus)

A combination formulation composed of a capsule containing the taxane compound paclitaxel and a tablet containing the multidrug resistance (MDR) efflux pump P-glycoprotein (P-gp) inhibitor HM30181A, with potential antineoplastic activity.

(Oraxol, NCI Thesaurus)