DENATURE

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does denature mean? 

• DENATURE (verb)
  The verb DENATURE has 3 senses:

1. add nonfissionable material to (fissionable material) so as to make unsuitable for use in an atomic bomb

2. modify (as a native protein) especially by heat, acid, alkali, or ultraviolet radiation so that all of the original properties are removed or diminished

3. make (alcohol) unfit for drinking without impairing usefulness for other purposes

  Familiarity information: DENATURE used as a verb is uncommon.

 Dictionary entry details 

• DENATURE (verb)

Present simple: I / you / we / they denature    ... he / she / it denatures   
Past simple: denatured   
Past participle: denatured   
-ing form: denaturing   

Sense 1

Meaning:

Add nonfissionable material to (fissionable material) so as to make unsuitable for use in an atomic bomb

Classified under:

Verbs of size, temperature change, intensifying, etc.

Hypernyms (to "denature" is one way to...):

alter; change; modify (cause to change; make different; cause a transformation)

Sentence frame:

Somebody ----s something

Derivation:

denaturant (any substance that serves as a denaturing agent)

Sense 2

Meaning:

Modify (as a native protein) especially by heat, acid, alkali, or ultraviolet radiation so that all of the original properties are removed or diminished

Classified under:

Verbs of size, temperature change, intensifying, etc.

Hypernyms (to "denature" is one way to...):

alter; change; modify (cause to change; make different; cause a transformation)

Sentence frame:

Somebody ----s something

Derivation:

denaturant (any substance that serves as a denaturing agent)

Sense 3

Meaning:

Make (alcohol) unfit for drinking without impairing usefulness for other purposes

Classified under:

Verbs of size, temperature change, intensifying, etc.

Hypernyms (to "denature" is one way to...):

alter; change; modify (cause to change; make different; cause a transformation)

Sentence frame:

Somebody ----s something

 Context examples 

Abnormal intracellular inclusions, composed of denatured hemoglobin, found on the membrane of red blood cells.

(Heinz Body, NLM, Medical Subject Headings)

The determination of the amount of Heinz bodies (denatured hemoglobin) present in a sample.

(Heinz-Ehrlich Body Measurement, NCI Thesaurus)

Altered migration of single-stranded DNA molecules in non-denaturing gels based upon 3-D conformation.

(Conformation Dependent Mutation Detection, NCI Thesaurus/OSP)

Although the exact mechanism of isopropanol's disinfecting action is not known, it might kill cells by denaturing cell proteins and DNA, interfering with cellular metabolism, and dissolving cell lipo-protein membranes.

(Isopropyl Alcohol, NCI Thesaurus)

First, a denatured DNA sample is treated with bisulfite which converts non-methylated cytosine to uracil.

(Bisulfite Sequencing, NCI Thesaurus)

This agent kills organisms by denaturing their proteins.

(Alcohol, NCI Thesaurus)

A humanized, affinity-matured IgG1k antibody directed against denatured collagens (I-IV) with potential antiangiogenic and antineoplastic activities.

(Anti-Denatured Collagen Monoclonal Antibody TRC093, NCI Thesaurus)

Then, the amplified DNA is treated with bisulfite twice under denaturing conditions, which converts non-methylated cytosine residues to uracil.

(MethylC-Seq, NCI Thesaurus)

Labeled DNAs were reacted with crude cell extracts and the complexes are run through a non-denaturing polyacrylamide gel.

(Electrophoretic Mobility Shift Assay, NCI Thesaurus)

By carefully selecting the denaturing temperature below the Tm for the wild-type molecule, only the mismatch heteroduplexes will melt and act as efficient templates for strand synthesis.

(COLD-PCR, NCI Thesaurus)