COLCHICINE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does colchicine mean? 

• COLCHICINE (noun)
  The noun COLCHICINE has 1 sense:

1. an analgesic drug derived from the saffron plant and used to treat gout

  Familiarity information: COLCHICINE used as a noun is very rare.

 Dictionary entry details 

• COLCHICINE (noun)

Sense 1

Meaning:

An analgesic drug derived from the saffron plant and used to treat gout

Classified under:

Nouns denoting man-made objects

Hypernyms ("colchicine" is a kind of...):

analgesic; anodyne; pain pill; painkiller (a medicine used to relieve pain)

 Context examples 

Overall, colchicine decreases leukocyte chemotaxis/migration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals.

(Colchicine, NCI Thesaurus)

Agents binding at the colchicine site produce a conformational change in the protofilament structure which subsequently impairs the polymerization of tubulin dimers and thereby prevents the formation of microtubules.

(Colchicine-Site Binding Agent, NCI Thesaurus)

CA1 binds to tubulin at the same site as colchicine but with higher affinity.

(Combretastatin A1 Diphosphate, NCI Thesaurus)

Ombrabulin binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells.

(Ombrabulin, NCI Thesaurus)

Although nocodazole binding site overlaps with that of colchicine, the two agents are structurally quite different.

(Nocodazole, NCI Thesaurus)

A colchicine analog with potential antimitotic and antineoplastic activities.

(Demecolcine, NCI Thesaurus)

Colchicine blocks cell division and the movement of certain immune cells to areas that are inflamed.

(Colchicine, NCI Dictionary)

However, the colchicine group showed improvement on the Homeostatic Model Assessment of Insulin Resistance test, which also estimates how much insulin is needed to keep blood sugar at a normal level while fasting.

(Gout treatment may help prevent obesity-related type 2 diabetes, National Institutes of Health)

The ombrabulin moiety of carbon C 14 ombrabulin binds to the colchicine binding site of endothelial cell tubulin, thereby inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells.

(Carbon C 14 Ombrabulin, NCI Thesaurus)

Benzoylphenylurea binds to the colchicine binding site on tubulin, thereby blocking tubulin polymerization and disrupting mitotic function.

(Benzoylphenylurea, NCI Thesaurus)