CLEAVAGE

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 Dictionary entry overview: What does cleavage mean? 

• CLEAVAGE (noun)
  The noun CLEAVAGE has 5 senses:

1. the state of being split or cleft

2. the breaking of a chemical bond in a molecule resulting in smaller molecules

3. (embryology) the repeated division of a fertilised ovum

4. the line formed by a groove between two parts (especially the separation between a woman's breasts)

5. the act of cleaving or splitting

  Familiarity information: CLEAVAGE used as a noun is common.

 Dictionary entry details 

• CLEAVAGE (noun)

Sense 1

Meaning:

The state of being split or cleft

Classified under:

Nouns denoting stable states of affairs

Context example:

there was a cleavage between the liberal and conservative members

Hypernyms ("cleavage" is a kind of...):

state (the way something is with respect to its main attributes)

Sense 2

Meaning:

The breaking of a chemical bond in a molecule resulting in smaller molecules

Classified under:

Nouns denoting natural processes

Hypernyms ("cleavage" is a kind of...):

chemical action; chemical change; chemical process ((chemistry) any process determined by the atomic and molecular composition and structure of the substances involved)

Sense 3

Meaning:

(embryology) the repeated division of a fertilised ovum

Classified under:

Nouns denoting natural processes

Synonyms:

cleavage; segmentation

Hypernyms ("cleavage" is a kind of...):

cell division; cellular division (the process in reproduction and growth by which a cell divides to form daughter cells)

Domain category:

embryology (the branch of biology that studies the formation and early development of living organisms)

Holonyms ("cleavage" is a part of...):

gestation; maternity; pregnancy (the state of being pregnant; the period from conception to birth when a woman carries a developing fetus in her uterus)

Sense 4

Meaning:

The line formed by a groove between two parts (especially the separation between a woman's breasts)

Classified under:

Nouns denoting body parts

Hypernyms ("cleavage" is a kind of...):

area; region (a part of an animal that has a special function or is supplied by a given artery or nerve)

Sense 5

Meaning:

The act of cleaving or splitting

Classified under:

Nouns denoting acts or actions

Hypernyms ("cleavage" is a kind of...):

division (the act or process of dividing)

Derivation:

cleave (separate or cut with a tool, such as a sharp instrument)

 Context examples 

This leads to the cleavage of poly (ADP-ribose) polymerase and the release of nuclear matrix proteins (NuMA).

(Mycobacterial Cell Wall-DNA Complex, NCI Thesaurus)

Preceded by extensive glycosylation, external proteolytic cleavage close to the plasma membrane may involve dimerization of the intracellular domain.

(Neuregulin 3, NCI Thesaurus)

Nibrin/gamma-H2AX associate with V(D)J recombination sites in response to RAG1-mediated cleavage.

(Nibrin, NCI Thesaurus)

Binding of the ligand Delta by Notch appears to trigger two proteolytic cleavages of Notch.

(Notch and Wnt Signaling Pathway, NCI Thesaurus/BIOCARTA)

After internalization of the drug conjugate and proteolytic cleavage of the linker, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M-phase growth arrest and tumor cell apoptosis.

(MUC16-targeted Antibody-Drug Conjugate DMUC5754A, NCI Thesaurus)

After internalization of the agent, the MMAE moiety is released by proteolytic cleavage.

(Anti-TF Monoclonal Antibody-MMAE Conjugate, NCI Thesaurus)

This protein is involved in both the structural integrity and completion of the cleavage furrow.

(Actin-Binding Protein Anillin, NCI Thesaurus)

Upon administration and internalization by LIV-1-positive tumor cells, anti-LIV-1 antibody-drug conjugate SGN-LIV1A undergoes enzymatic cleavage to release MMAE into the cytosol.

(Anti-LIV-1 Monoclonal Antibody-MMAE Conjugate SGN-LIV1A, NCI Thesaurus)

After internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis in nectin-4 overexpressing tumor cells.

(Anti-nectin-4 Monoclonal Antibody-Drug Conjugate AGS-22M6E, NCI Thesaurus)

Upon cleavage, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and tumor cell apoptosis.

(Anti-SLITRK6 Monoclonal Antibody-MMAE Conjugate AGS15E, NCI Thesaurus)