CITRULLINE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does citrulline mean? 

• CITRULLINE (noun)
  The noun CITRULLINE has 1 sense:

1. an amino acid that does not occur in proteins but is an intermediate in the conversion of ornithine to arginine

  Familiarity information: CITRULLINE used as a noun is very rare.

 Dictionary entry details 

• CITRULLINE (noun)

Sense 1

Meaning:

An amino acid that does not occur in proteins but is an intermediate in the conversion of ornithine to arginine

Classified under:

Nouns denoting substances

Hypernyms ("citrulline" is a kind of...):

amino acid; aminoalkanoic acid (organic compounds containing an amino group and a carboxylic acid group)

 Context examples 

Arginine is the only physiological substrate for NOS which, in eukaryotic cells, generates NO and L-citrulline from L-arginine and molecular oxygen in a five-electron transfer reaction.

(Amino-Arginine, NCI Thesaurus)

The enzyme ornithine transcarbamoylase is found in mitochondria and converts ornithine into citrulline.

(Feeding Amino Groups into the Urea Cycle, NCI Thesaurus/BIOCARTA)

L-citrulline is converted into L-arginine by the enzymes argininosuccinate synthetase and argininosuccinate lyase in the presence of L-aspartate and ATP.

(Citrulline, NCI Thesaurus)

The dephosphorylation of nNOS by Calcineurin catalyzes the conversion of arginine to citrulline and nitric oxide (NO), which turns on guanylate cyclase and the various cGMP regulated signaling pathways.

(Nitric Oxide Signaling Pathway, NCI Thesaurus/BIOCARTA)

Upon administration, arginine deiminase breaks down the amino acid arginine into citrulline.

(Pegylated arginine deiminase, NCI Thesaurus)

Brentuximab vedotin is generated by conjugating the chimeric anti-CD30 monoclonal antibody SGN-30 to the cytotoxic agent monomethyl auristatin E (MMAE) via a valine-citrulline peptide linker.

(Brentuximab vedotin, NCI Thesaurus)

As L. brevis CD2 contains high levels of arginine deiminase, which catalyzes the conversion of arginine to citrulline and ammonia, administration of this lozenge leads to hydrolysis of arginine in the oral cavity.

(Lactobacillus brevis CD2 Lozenge, NCI Thesaurus)

An antibody drug conjugate (ADC) containing the fully human IgG2k monoclonal antibody targeting an epitope of SLC44A4 (AGS-5) linked, via a valine-citrulline (vc) maleimidocaproyl (mc) linker, to the antimicrotubulin drug monomethyl auristatin E (MMAE), with potential antineoplastic activity.

(Anti-AGS-5 Antibody-Drug Conjugate ASG-5ME, NCI Thesaurus)

An antibody-drug conjugate, consisting of the fully human monoclonal antibody CR011 directed against glycoprotein NMB (GPNMB) and conjugated via a cathepsin B-sensitive valine-citrulline (vc) linkage to the cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity.

(Glembatumumab Vedotin, NCI Thesaurus)

Citrulline is exported into the cytoplasm where another nitrogen for urea is acquired from aspartate, followed by the release of fumarate to form the amino acid arginine.

(Feeding Amino Groups into the Urea Cycle, NCI Thesaurus/BIOCARTA)