SCID

Pronunciation (US):

(GB):

 Dictionary entry overview: What does SCID mean? 

• SCID (noun)
  The noun SCID has 1 sense:

1. a congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life

  Familiarity information: SCID used as a noun is very rare.

 Dictionary entry details 

• SCID (noun)

Sense 1

Meaning:

A congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life

Classified under:

Nouns denoting stable states of affairs

Synonyms:

SCID; severe combined immunodeficiency; severe combined immunodeficiency disease

Hypernyms ("SCID" is a kind of...):

immunodeficiency (immunological disorder in which some part of the body's immune system is inadequate and resistance to infectious diseases is reduced)

monogenic disease; monogenic disorder (an inherited disease controlled by a single pair of genes)

Hyponyms (each of the following is a kind of "SCID"):

ADA-SCID (SCID resulting from mutation of a gene that codes for adenosine deaminase)

X-linked SCID; X-SCID (SCID in male children resulting from mutation of a gene that codes for a protein on the surface of T cells that allows them to develop a growth factor receptor)

 Context examples 

The most common form of SCID, accounting for about 50% of autosomal recessive cases.

(Adenosine Deaminase Deficiency, NCI Thesaurus)

Infants with X-SCID, caused by mutations in the IL2RG gene, are highly susceptible to severe infections.

(Gene therapy restores immunity in infants with rare immunodeficiency disease, National Institutes of Health)

Certain allelic variants of the CD3D gene cause a form of severe combined immunodeficiency (SCID) characterized by the absence of T cells but normal numbers of B cells and NK cells.

(CD3D wt Allele, NCI Thesaurus)

Some humans with SCID (severe combined immunodeficiency disease) also have mutation of their IL-7 receptor gene leading to an absence of T cells and greatly impaired B cell production.

(IL7 Signaling Pathway, NCI Thesaurus/BIOCARTA)

Also called: Severe Combined Immunodeficiency, SCID

(Immune System and Disorders, NIH: National Institute of Allergy and Infectious Diseases)

Stem cell transplantation can fully correct the T-cell and, less consistently, the B-cell deficiencies of SCID infants.

(Early treatment benefits infants with severe combined immunodeficiency, NIH)

Upon re-infusion of the EFS-ADA vector-transduced lymphocytes back into the patient, these cells may both restore ADA activity and prevent severe combined immunodeficiency (SCID) due to ADA deficiency.

(EFS-ADA Lentiviral Vector-transduced CD34-positive Autologous Lymphocytes, NCI Thesaurus)

ADA catalyzes the hydrolysis of adenosine to inosine; ADA deficiency causes a form of severe combined immunodeficiency (SCID).

(ADA Transduced T Cell, NCI Thesaurus)

Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extraembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution.

(ES01, NCI Thesaurus)

The new approach appears safer and more effective than previously tested gene-therapy strategies for X-SCID.

(Gene therapy restores immunity in infants with rare immunodeficiency disease, National Institutes of Health)