ZIDOVUDINE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does zidovudine mean? 

• ZIDOVUDINE (noun)
  The noun ZIDOVUDINE has 1 sense:

1. an antiviral drug (trade name Retrovir) used in the treatment of AIDS; adverse side effects include liver damage and suppression of the bone marrow

  Familiarity information: ZIDOVUDINE used as a noun is very rare.

 Dictionary entry details 

• ZIDOVUDINE (noun)

Sense 1

Meaning:

An antiviral drug (trade name Retrovir) used in the treatment of AIDS; adverse side effects include liver damage and suppression of the bone marrow

Classified under:

Nouns denoting man-made objects

Synonyms:

AZT; Retrovir; ZDV; zidovudine

Hypernyms ("zidovudine" is a kind of...):

NRTI; nucleoside reverse transcriptase inhibitor (an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs)

 Context examples 

UC-781 is a potent inhibitor of reverse transcriptase-dependent pyrophosphorolysis, and purportedly restores the chain-terminating activity of zidovudine (AZT) against AZT-resistant virus.

(N-(4-Chloro-3-((3-Methyl-2-Butenyl)Oxy)Phenyl)-2-Methyl-3-Furancarbothioamide, NCI Thesaurus)

Lamivudine is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP); zidovudine is phosphorylated to its active 5'-triphosphate metabolite, zidovudine triphosphate (ZDV-TP).

(Lamivudine/Zidovudine, NCI Thesaurus)

A dideoxyuridine inhibitor of HIV reverse transcriptase that is related to zidovudine.

(Navuridine, NCI Thesaurus)

Also called zidovudine.

(AZT, NCI Dictionary)