VON WILLEBRAND

Pronunciation (US):

(GB):

• VON WILLEBRAND (noun)
  The noun VON WILLEBRAND has 1 sense:

1. Finnish physician who first described vascular hemophilia (1870-1949)

  Familiarity information: VON WILLEBRAND used as a noun is very rare.

• VON WILLEBRAND (noun)

Sense 1

Meaning:

Finnish physician who first described vascular hemophilia (1870-1949)

Classified under:

Nouns denoting people

Synonyms:

E. A. von Willebrand; Erik Adolf von Willebrand; Erik von Willebrand; von Willebrand; Willebrand

Instance hypernyms:

doc; doctor; Dr.; MD; medico; physician (a licensed medical practitioner)

 Context examples 

Also called: Blood Platelet Disorders, von Willebrand's Disease

(Platelet Disorders, NIH: National Heart, Lung, and Blood Institute)

Multiple heterodimeric alpha/beta combinations result in different integrins. aV/beta-3 is a receptor for cytotactin, fibronectin, laminin, MMP-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin, and von Willebrand factor.

(Integrin AlphaV/Beta3, NCI Thesaurus)

The protein is an extracellular anti-hemophilic factor that is part of the von Willebrand factor complex.

(Coagulation Factor VIII, NCI Thesaurus)

This prevents the binding of fibrinogen, von Willebrand factor, and other adhesive ligands and leads to an inhibition of platelet aggregation and prevents thrombus development.

(Eptifibatide, NCI Thesaurus)

Desmopressin binds to V2 receptors in renal collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption.

(Desmopressin, NCI Thesaurus)

An unrelated action of desmopressin acetate is to increases circulating factor VIII and is used in patients with haemophilia and von Willebrand's disease.

(Desmopressin Acetate, NCI Thesaurus)

Glycoprotein IIb/IIIa antagonists bind to and block the activation of the platelet-surface integrin glycoprotein IIb/IIIa, thus preventing the binding of fibrinogen and von Willebrand factor leading to the inhibition of platelet activation and aggregation.

(Glycoprotein IIb/IIIa Antagonist, NCI Thesaurus)

For example, in von Willebrand Disease, the platelets cannot stick together or cannot attach to blood vessel walls.

(Platelet Disorders, NIH: National Heart, Lung, and Blood Institute)