TNF

Pronunciation (US):

(GB):

 Dictionary entry overview: What does TNF mean? 

• TNF (noun)
  The noun TNF has 1 sense:

1. a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)

  Familiarity information: TNF used as a noun is very rare.

 Dictionary entry details 

• TNF (noun)

Sense 1

Meaning:

A proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)

Classified under:

Nouns denoting substances

Synonyms:

TNF; tumor necrosis factor; tumour necrosis factor

Hypernyms ("TNF" is a kind of...):

cytokine (any of various protein molecules secreted by cells of the immune system that serve to regulate the immune system)

 Context examples 

OX-40 is a type of tumor necrosis factor (TNF) receptor.

(OX-40, NCI Dictionary)

APRIL and BAFF (also called TALL-I and BLyS) are TNF family members that act as ligands for the BCMA and TACI receptors.

(B-Cell Immune Response Pathway, NCI Thesaurus/BIOCARTA)

TNF inhibitors are also used to treat chronic inflammatory diseases such as rheumatoid arthritis.

(Researchers discover otulipenia, a new inflammatory disease, NIH)

In addition, this agent modulates inflammatory responses through various mechanisms, including the inhibition of both the release of reactive oxygen species (ROS) from neutrophils and tumor necrosis factor (TNF)-alpha activity.

(PI3K Delta/Gamma Inhibitor RP6530, NCI Thesaurus)

These receptors are present on many cells, including immune cells, and it's this activation that leads to changes in the body's immune system response, including a decrease in cells producing TNF.

(Just 20 Minutes of Walking May Reduce Inflammation in Your Body, The Titi Tudorancea Bulletin)

Moreover activated mast cells and Th2 cells in the lung generate the cytokines interleukin IL-4, IL-13 and tumour necrosis factor (TNF)-alpha.

(Asthma Pathway, NCI Thesaurus/KEGG)

Aurimmune is made in the laboratory by binding a cancer-killing protein called tumor necrosis factor (TNF) to the surface of very tiny particles of gold.

(Aurimmune, NCI Dictionary)

Inflammatory molecules that activate neutrophils include IL-1, TNF, IL-6, C-reactive protein, C3a and C5a complement anaphylatoxins, leukotrienes, PAF, and histamine.

(Neutrophil Surface Molecule Pathway, NCI Thesaurus/BIOCARTA)

In addition to activation of inflammatory cytokine genes like IL-1 and TNF, H. influenzae activates TLR2 expression and genes involved in mucus production.

(NFKB Activation Pathway, NCI Thesaurus/BIOCARTA)

TNF family receptors that cause apoptosis directly activate the caspase cascade, but can also activate Bid, a Bcl-2 family member, which activates mitochondria-mediated apoptosis.

(Mitochondria in Apoptotic Signaling Pathway, NCI Thesaurus/BIOCARTA)