THROMBIN

Pronunciation (US):

(GB):

 Dictionary entry overview: What does thrombin mean? 

• THROMBIN (noun)
  The noun THROMBIN has 1 sense:

1. an enzyme that acts on fibrinogen in blood causing it to clot

  Familiarity information: THROMBIN used as a noun is very rare.

 Dictionary entry details 

• THROMBIN (noun)

Sense 1

Meaning:

An enzyme that acts on fibrinogen in blood causing it to clot

Classified under:

Nouns denoting substances

Hypernyms ("thrombin" is a kind of...):

coagulase (an enzyme that induces coagulation)

 Context examples 

One NIH unit equals 1.1 to 1.3 International Units of thrombin.

(NIH Unit of Thrombin Inhibited/Square Centimeter, NCI Thesaurus)

Endothelial cells respond to treatment with the protease thrombin with increased secretion of the PDGF B-chain.

(DBPB Transcriptional Activation Pathway, NCI Thesaurus/BIOCARTA)

Argatroban is a univalent and direct inhibitor of fibrin-bound thrombin.

(Argatroban, NCI Thesaurus)

Antithrombin alfa blocks thrombin activity and thus thrombus formation.

(Antithrombin Alfa, NCI Thesaurus)

In turn, factor Xa/Va complex activates thrombin, which cleaves fibrinogen into fibrin, eventually resulting in blood clot formation.

(Antihemophilic Factor, Human Recombinant, NCI Thesaurus)

This may prevent thrombin formation and cancer-associated venous thromboembolism, and may inhibit angiogenesis and tumor cell proliferation.

(Anti-TF Monoclonal Antibody ALT-836, NCI Thesaurus)

Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity.

(Complement and Coagulation Cascade, NCI Thesaurus/KEGG)

Danaparoid sodium binds to antithrombin III and inhibits the activity of activated factor X (factor Xa) and, to a lesser extent, activated factor II (thrombin) thereby preventing fibrin formation.

(Danaparoid Sodium, NCI Thesaurus)

Agonists such as ADP, thrombin, epinephrine and collagen activate the release of APP and plasminogen activator inhibitor I (an important regulator of coagulation) from platelet storage granules.

(Platelet Amyloid Precursor Protein Pathway, NCI Thesaurus/BIOCARTA)

This prevents the activation of vitamin K-dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S, which abrogates both thrombin production and thrombus formation.

(Phenprocoumon, NCI Thesaurus)