TAMOXIFEN

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does tamoxifen mean? 

• TAMOXIFEN (noun)
  The noun TAMOXIFEN has 1 sense:

1. an antagonist for estrogen that is used in the treatment of breast cancer

  Familiarity information: TAMOXIFEN used as a noun is very rare.

 Dictionary entry details 

• TAMOXIFEN (noun)

Sense 1

Meaning:

An antagonist for estrogen that is used in the treatment of breast cancer

Classified under:

Nouns denoting man-made objects

Synonyms:

estrogen antagonist; tamoxifen

Hypernyms ("tamoxifen" is a kind of...):

antagonist (a drug that neutralizes or counteracts the effects of another drug)

 Context examples 

The (13)C-dextromethorphan breath test may prove useful in identifying poor CYP2D6 metabolizers of such important clinical drugs as tamoxifen.

(Carbon C-13 Dextromethorphan, NCI Thesaurus)

The interaction of estrogen receptor with various ligand-dependent coactivators may produce the tissue selective response of some estrogen receptor ligands like tamoxifen.

(Estrogen Receptor Regulation by CARM1 Pathway, NCI Thesaurus/BIOCARTA)

Conversion of N-desmethyltamoxifen from tamoxifen is catalyzed by cytochrome P-450 enzymes 3A4 and 3A5.

(N-Desmethyltamoxifen, NCI Thesaurus)

Oncotype DX is validated for use in breast cancer patients whose disease is newly diagnosed, stage I or II, node-negative, estrogen receptor-positive and who will be treated with tamoxifen.

(Oncotype DX breast cancer assay, NCI Thesaurus)

They then injected the mice with TSA and tamoxifen.

(Researchers unlock regenerative potential of cells in the mouse retina, National Institutes of Health)

The BCPT also looked at whether taking tamoxifen would decrease the number of heart attacks and reduce the number of bone fractures in these women.

(Breast Cancer Prevention Trial, NCI Thesaurus)

Afimoxifene has a higher affinity for the estrogen receptor than tamoxifen, and functions as an antagonist in breast cancer cells.

(Afimoxifene, NCI Thesaurus)

This agent exhibits greater bioavailability and higher anti-estrogenic potency in the breast than does raloxifene; it exhibits reduced estrogenicity in the uterus compared with either tamoxifen or raloxifene.

(Arzoxifene, NCI Thesaurus)

A regimen consisting of tamoxifen, cisplatin, dacarbazine and carmustine used for the treatment of advanced-stage or metastatic malignant melanoma.

(Dartmouth Regimen, NCI Thesaurus)

A drug used to treat advanced breast cancer and to prevent recurrent breast cancer in postmenopausal women who have already been treated with tamoxifen.

(Aromasin, NCI Dictionary)