SUBSTITUTION

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 Dictionary entry overview: What does substitution mean? 

• SUBSTITUTION (noun)
  The noun SUBSTITUTION has 2 senses:

1. an event in which one thing is substituted for another

2. the act of putting one thing or person in the place of another:

  Familiarity information: SUBSTITUTION used as a noun is rare.

 Dictionary entry details 

• SUBSTITUTION (noun)

Sense 1

Meaning:

An event in which one thing is substituted for another

Classified under:

Nouns denoting natural events

Synonyms:

permutation; replacement; substitution; switch; transposition

Context example:

the replacement of lost blood by a transfusion of donor blood

Hypernyms ("substitution" is a kind of...):

fluctuation; variation (an instance of change; the rate or magnitude of change)

Derivation:

substitute (put in the place of another; switch seemingly equivalent items)

substitute (be a substitute)

Sense 2

Meaning:

The act of putting one thing or person in the place of another:

Classified under:

Nouns denoting acts or actions

Synonyms:

commutation; exchange; substitution

Context example:

he sent Smith in for Jones but the substitution came too late to help

Hypernyms ("substitution" is a kind of...):

change (the action of changing something)

Hyponyms (each of the following is a kind of "substitution"):

replacement; replacing (the act of furnishing an equivalent person or thing in the place of another)

subrogation ((law) the act of substituting of one creditor for another)

ablactation; weaning (the act of substituting other food for the mother's milk in the diet of a child or young mammal)

Derivation:

substitute (put in the place of another; switch seemingly equivalent items)

 Context examples 

NOTE(S): The message text may contain substitution tags that when used in the context of a particular study are replaced with study name or study site, etc.

(Defined Notification Message, NCI Thesaurus/BRIDG)

Single nucleotide substitutions and small deletions or insertions (1-20 bases) account for the majority of mutations in the BRCA1 gene.

(BRCA1 Gene Mutation, NCI Thesaurus)

Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity.

(Dimerizer AP1903, NCI Thesaurus)

Any substitutions on carbon or nitrogen atoms are permitted.

(Ethylenimine Compound, NLM, Medical Subject Headings)

“There has been a substitution of lodgers. What I did not foresee is that we should find a woman, and no ordinary woman, Watson.”

(His Last Bow, by Sir Arthur Conan Doyle)

The valine to glutamic acid substitution at residue 600 (V600E) accounts for about 90% of BRAF gene mutations.

(BRAF Inhibitor ARQ 736, NCI Thesaurus)

A recombinant peptide derived from the human melanoma antigen glycoprotein 100 (gp100) with potential use in cancer immunotherapy. gp100 protein(184V) has a valine substitution at position 184.

(gp100 Protein (184V), NCI Thesaurus)

PEP223 is dimerized and contains a D-lysine (k) substitution at position 6 (pyroEHWSYkLRPG) to increase its immunogenicity.

(Anti-GnRH Vaccine PEP223, NCI Thesaurus)

The most thoroughly studied cancer-associated mutations involve the substitution of one nucleotide of DNA for another in genes known as oncogenes and tumor suppressors.

(Researchers uncover role of repetitive DNA and protein sequences in tumor evolution, National Institutes of Health)

A point mutation involving the substitution of Thymidine (a pyrimidine base) for Guanosine (a purine base) in a DNA sequence from eukaryotic or prokaryotic organisms.

(Guanosine to Thymidine Transversion Abnormality, NCI Thesaurus)