POTENTIATE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does potentiate mean? 

• POTENTIATE (verb)
  The verb POTENTIATE has 1 sense:

1. increase the effect of or act synergistically with (a drug or a physiological or biochemical phenomenon)

  Familiarity information: POTENTIATE used as a verb is very rare.

 Dictionary entry details 

• POTENTIATE (verb)

Present simple: I / you / we / they potentiate    ... he / she / it potentiates   
Past simple: potentiated   
Past participle: potentiated   
-ing form: potentiating   

Sense 1

Meaning:

Increase the effect of or act synergistically with (a drug or a physiological or biochemical phenomenon)

Classified under:

Verbs of size, temperature change, intensifying, etc.

Context example:

potentiate the drug

Hypernyms (to "potentiate" is one way to...):

enhance; heighten; raise (increase)

Domain category:

drug (a substance that is used as a medicine or narcotic)

Sentence frame:

Something ----s something

Derivation:

potentiation ((medicine) the synergistic effect of two drugs given simultaneously)

 Context examples 

As a selective serotonin reuptake inhibitor (SSRI), citalopram selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system (CNS).

(Citalopram Hydrobromide, NCI Thesaurus)

This agent may potentiate the immune response to vaccines against various liver neoplasms.

(Attenuated Listeria monocytogenes CRS-100, NCI Thesaurus)

Upon administration of CDX-1127, this MoAb binds to CD27 and may potentiate the immune response by increasing the cytotoxic T-lymphocyte (CTL) response against CD27-expressing tumor cells.

(Anti-CD27 Monoclonal Antibody CDX-1127, NCI Thesaurus)

A medication containing two or more active ingredients acting in a synergistic or potentiating manner to treat a disease state.

(Combination Medication, NCI Thesaurus)

GM-CSF potentiates the antitumor immune response.

(E75 Peptide Plus GM-CSF Vaccine, NCI Thesaurus)

CEP-8983 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance.

(PARP Inhibitor CEP-9722, NCI Thesaurus)

Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA.

(O6-Benzylguanine, NCI Thesaurus)

Anguidine also has been shown to both potentiate and protect against the cytotoxic effects of other drugs.

(Anguidine, NCI Thesaurus)

Fc-mediated binding of APCs in the tricellular complex potentiates EpCAM antigen presentation to T cells and the activation of anti-tumor cytotoxic T cell functions.

(Catumaxomab, NCI Thesaurus)

Upon vaccination, allogeneic GM-CSF-based myeloma cellular vaccine secretes GM-CSF, which may potentiate a tumor-specific cytotoxic T-lymphocyte (CTL) response against myeloma cancer cell-associated antigens.

(Allogeneic GM-CSF-Based Myeloma Cell Vaccine, NCI Thesaurus)