OXALOACETATE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does oxaloacetate mean? 

• OXALOACETATE (noun)
  The noun OXALOACETATE has 1 sense:

1. a salt or ester of oxalacetic acid

  Familiarity information: OXALOACETATE used as a noun is very rare.

 Dictionary entry details 

• OXALOACETATE (noun)

Sense 1

Meaning:

A salt or ester of oxalacetic acid

Classified under:

Nouns denoting substances

Synonyms:

oxalacetate; oxaloacetate

Hypernyms ("oxaloacetate" is a kind of...):

salt (a compound formed by replacing hydrogen in an acid by a metal (or a radical that acts like a metal))

 Context examples 

As part of the Kreb's cycle, the carbon skeleton of oxaloacetate can generate energy and provide material for biosynthesis.

(Catabolic Pathway for Asparagine and Aspartate, NCI Thesaurus/BIOCARTA)

At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate.

(Citrate Cycle (TCA Cycle) Pathway, NCI Thesaurus/KEGG)

This allele, which encodes aspartate aminotransferase, cytoplasmic protein, is involved in the reversible transamination between L-aspartate and 2-oxoglutarate to form oxaloacetate and L-glutamate.

(GOT1 wt Allele, NCI Thesaurus)

This allele, which encodes aspartate aminotransferase, mitochondrial protein, plays a role in the transamination between L-aspartate and 2-oxoglutarate to form oxaloacetate and L-glutamate.

(GOT2 wt Allele, NCI Thesaurus)

Inside mitochondria, the enzyme citrate synthase joins acetyl-CoA with oxaloacetate to make citrate.

(Acetyl Group Shuttle Pathway, NCI Thesaurus/BIOCARTA)

The transfer of the amino group from aspartate to alpha-ketobutyrate creates oxaloacetate, a Krebs cycle intermediate.

(Feeding Amino Groups into the Urea Cycle, NCI Thesaurus/BIOCARTA)

The Gly-rich NAD-Binding Domain (often N-terminal) is often found in metabolic enzymes involved in glycolysis, glyconeogenesis, and the citric acid cycle, such as GAPDH (glyceraldehyde-3-phosphate oxidation and phosphorylation), lactate dehydrogenases (lactate to pyruvate conversion), and malate dehydrogenases (malate to oxaloacetate interconversion).

(NAD-Binding Domain, NCI Thesaurus)

The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate.

(Citrate Cycle (TCA Cycle) Pathway, NCI Thesaurus/KEGG)

Once in the cytosol, the citrate is converted back to oxaloacetate, which is then reduced to malate.

(Acetyl Group Shuttle Pathway, NCI Thesaurus/BIOCARTA)

Aspartate is then transaminated by aspartate transaminase to exchange its amino group onto alpha-ketoglutarate and be converted into oxaloacetate.

(Catabolic Pathway for Asparagine and Aspartate, NCI Thesaurus/BIOCARTA)