OSTEOCLAST

Pronunciation (US):

(GB):

 Dictionary entry overview: What does osteoclast mean? 

• OSTEOCLAST (noun)
  The noun OSTEOCLAST has 1 sense:

1. cell that functions in the breakdown and resorption of bone tissue

  Familiarity information: OSTEOCLAST used as a noun is very rare.

 Dictionary entry details 

• OSTEOCLAST (noun)

Sense 1

Meaning:

Cell that functions in the breakdown and resorption of bone tissue

Classified under:

Nouns denoting body parts

Hypernyms ("osteoclast" is a kind of...):

bone cell (a cell that is part of a bone)

 Context examples 

This prevents farnesylation and geranylgeranylation of proteins essential for osteoclast function, leading to the induction of apoptosis of osteoclasts.

(Pamidronic Acid, NCI Thesaurus)

PU.1 is thought to regulate transcription of FMS and CD18/11B, proteins central to the osteoclast phenotype, and is required for p47-phox promoter activity in myeloid cells.

(Oncogene SPI1, NCI Thesaurus)

RANK (receptor activator of NF-kB ligand) is a receptor in the TNF receptor gene family that is involved in osteoclast differentiation.

(Bone Remodeling Pathway, NCI Thesaurus/BIOCARTA)

This leads to the loss of activity of proteins involved in osteoclast function and cellular proliferation, such as Ras and Rho, leading to an inhibition of cellular proliferation, and induction of osteoclasts apoptosis.

(Apomine, NCI Thesaurus)

As a result, osteoclast activity is inhibited and bone resorption and turnover are reduced.

(Alendronate sodium, NCI Thesaurus)

It contains connective tissue, capillaries, nerves, and a number of types of cell, including osteoclasts.

(Periosteum, NCI Thesaurus)

Anti-M-CSF monoclonal antibody MCS110 binds to M-CSF and blocks M-CSF-mediated signaling through the M-CSF receptor CD116 expressed on osteoclasts, which may result in inhibition of M-CSF-induced osteoclast differentiation and so osteoclastic bone resorption.

(Anti-M-CSF Monoclonal Antibody MCS110, NCI Thesaurus)

Although the exact mechanism of action has yet to be fully elucidated, neridronic acid binds to and adsorbs onto hydroxyapatite crystals in bone matrix, thereby preventing osteoclast resorption.

(Neridronic Acid, NCI Thesaurus)

Bone resorption of type I collagen by osteoclasts results in the release of this peptide.

(N-Telopeptide, NCI Thesaurus)

It is a distinctive tumor, which usually displays the following morphologic characteristics: low cellularity, myxoid changes, presence of spindled cells and osteoclasts, hemangiopericytoma-like vessels, hemorrhage, and osteoid-like matrix.

(Phosphaturic Mesenchymal Tumor, NCI Thesaurus)