NUCLEASE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does nuclease mean? 

• NUCLEASE (noun)
  The noun NUCLEASE has 1 sense:

1. general term for enzymes that catalyze the hydrolysis of nucleic acid by cleaving chains of nucleotides into smaller units

  Familiarity information: NUCLEASE used as a noun is very rare.

 Dictionary entry details 

• NUCLEASE (noun)

Sense 1

Meaning:

General term for enzymes that catalyze the hydrolysis of nucleic acid by cleaving chains of nucleotides into smaller units

Classified under:

Nouns denoting substances

Hypernyms ("nuclease" is a kind of...):

enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)

Hyponyms (each of the following is a kind of "nuclease"):

endonuclease (a nuclease that cleaves nucleic acids at interior bonds and so produces fragments of various sizes)

exonuclease (a nuclease that releases one nucleotide at a time (serially) beginning at one of a nucleic acid)

 Context examples 

The multifunctional nuclease APE1 is a key component for DNA repair; its expression is often correlated with tumor cell resistance to radio- and chemotherapy.

(Lucanthone, NCI Thesaurus)

An Exonuclease is a hydrolase (nuclease) that specifically catalyzes the hydrolysis of terminal phosphodiester bonds of deoxyribonucleotide or ribonucleotide chains, releasing mononucleotides.

(Exonuclease, NCI Thesaurus)

This allele, which encodes Fanconi-associated nuclease 1 protein, plays a role in the modulation of DNA repair.

(FAN1 wt Allele, NCI Thesaurus)

A molecular genetic technique where genome-wide sequencing is performed on chromosomal DNA that is resistant to treatment with micrococcal nuclease.

(MNase Sequencing, NCI Thesaurus)

In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis.

(Brivudine, NCI Thesaurus)

DNA binding by AIF stimulates chromatin condensation, and DNA fragmentation, perhaps through recruitment of nucleases.

(AIF Pathway, NCI Thesaurus/BIOCARTA)

This activity is conducted by multiple nucleases activated by apoptotic signaling pathways.

(Apoptotic DNA Fragmentation Pathway, NCI Thesaurus/BIOCARTA)

Enzymes (EC class 3) cleaving substrates with addition of H2O at the point of cleavage; e.g., esterases, phosphatases, nucleases, peptidases.

(Hydrolase, NCI Thesaurus)

The protein, which exhibits bidirectional nuclease activity is required for both DNA synthesis and repair.

(DNA Polymerase Alpha, NCI Thesaurus)

The gene therapy treatment, known as the mitochondrially targeted zinc finger-nuclease, or mtZFN, recognises and then eliminates the mutant mitochondrial DNA, based on the DNA sequence differences between healthy and mutant mitochondrial DNA.

(Mitochondrial diseases could be treated with gene therapy, The Titi Tudorancea Bulletin)