NAIVE

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 Dictionary entry overview: What does naive mean? 

• NAIVE (adjective)
  The adjective NAIVE has 5 senses:

1. marked by or showing unaffected simplicity and lack of guile or worldly experience

2. of or created by one without formal training; simple or naive in style

3. inexperienced

4. lacking information or instruction

5. not initiated; deficient in relevant experience

  Familiarity information: NAIVE used as an adjective is common.

 Dictionary entry details 

• NAIVE (adjective)

Sense 1

Meaning:

Marked by or showing unaffected simplicity and lack of guile or worldly experience

Synonyms:

naif; naive

Context example:

this naive simple creature with wide friendly eyes so eager to believe appearances

Similar:

childlike; dewy-eyed; round-eyed; simple; wide-eyed (exhibiting childlike simplicity and credulity)

credulous (showing a lack of judgment or experience)

fleeceable; green; gullible (naive and easily deceived or tricked)

ingenuous; innocent (lacking in sophistication or worldliness)

simple-minded (lacking subtlety and insight)

unsophisticated; unworldly (not wise in the ways of the world)

Also:

credulous (disposed to believe on little evidence)

uninformed (not informed; lacking in knowledge or information)

unworldly (not concerned with the temporal world or swayed by mundane considerations)

Antonym:

sophisticated (having or appealing to those having worldly knowledge and refinement and savoir-faire)

Derivation:

naiveness (lack of sophistication or worldliness)

Sense 2

Meaning:

Of or created by one without formal training; simple or naive in style

Synonyms:

naive; primitive

Context example:

primitive art such as that by Grandma Moses is often colorful and striking

Similar:

untrained (not disciplined or conditioned or made adept by training)

Domain category:

beaux arts; fine arts (the study and creation of visual works of art)

Sense 3

Meaning:

Inexperienced

Similar:

innate; unconditioned; unlearned (not established by conditioning or learning)

Derivation:

naiveness (lack of sophistication or worldliness)

Sense 4

Meaning:

Lacking information or instruction

Synonyms:

naive; unenlightened; uninstructed

Context example:

lamentably unenlightened as to the laws

Similar:

uninformed (not informed; lacking in knowledge or information)

Derivation:

naiveness (lack of sophistication or worldliness)

Sense 5

Meaning:

Not initiated; deficient in relevant experience

Synonyms:

naive; uninitiate; uninitiated

Context example:

he took part in the experiment as a naive subject

Similar:

inexperienced; inexperient (lacking practical experience or training)

Derivation:

naiveness (lack of sophistication or worldliness)

 Context examples 

Dendritic cells infected with TRICOM vectors greatly enhance naive T-cell activation and peptide-specific T-cell stimulation.

(Fowlpox-PSA-TRICOM Vaccine, NCI Thesaurus)

The recognition of this variant alters the belief that CLL/SLL is always derived from a naive, pregerminal center B-cell.

(Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation, NCI Thesaurus)

This isotype is expressed on naive B cells along with IgM.

(IgD, NCI Thesaurus)

"Do you think you shall like Morton?" she asked of me, with a direct and naive simplicity of tone and manner, pleasing, if child-like.

(Jane Eyre, by Charlotte Brontë)

Upon recognition of the antigen and activation by APC, naive T cells differentiate into Th2 cells, a process that is promoted by interleukin 4 (IL-4).

(Asthma Pathway, NCI Thesaurus/KEGG)

This allele, which encodes small inducible cytokine A18 protein, is involved in the chemotactic regulation of naive T cells, CD4+ and CD8+ T cells, and nonactivated lymphocytes involved in inflammatory processes.

(CCL18 wt Allele, NCI Thesaurus)

A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.

(Interleukin-2, NLM, Medical Subject Headings)

Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines.

(Gusperimus Trihydrochloride, NCI Thesaurus)

As an immunostimulatory sequence (ISS) that signals through Toll-like receptor 9 (TLR9), ISS 1018 CpG ODN induces the production of immunoglobulin by B cells and interferon (IFN) -alpha, IFN-beta, interleukin (IL) -12, and tumor necrosis factor (TNF) -alpha by plasmacytoid dendritic cells (pDC). pDC, through cell-cell contact, and IFN-alpha and -beta, in turn, induce natural killer (NK) cell proliferation, NK cell production of IFN-gamma, and NK cell-mediated cytotoxicity; secreted IFNs also stimulate bystander T cell activation and differentiation of naive CD4+ T cells into T-helper 1 cells on specific antigen challenge.

(ISS 1018 CpG Oligodeoxynucleotide, NCI Thesaurus)

Induced by glucocorticoids, PMA, IL-4, IL-13, and IL-10 and expressed by human CCL18 Gene (Intercrine Beta Family) in lung, lymph nodes, placenta, bone marrow, dendritic cells, and macrophages, secreted 89-aa 10-kDa (precursor) Small Inducible Cytokine A18, an immunoregulatory chemotactic cytokine for naive T cells, CD4+ and CD8+ T cells, and nonactivated lymphocytes involved in inflammatory processes s well as humoral and cell-mediated immunity.

(C-C Motif Chemokine 18, NCI Thesaurus)