MITOGEN

Pronunciation (US):

(GB):

 Dictionary entry overview: What does mitogen mean? 

• MITOGEN (noun)
  The noun MITOGEN has 1 sense:

1. an agent that triggers mitosis

  Familiarity information: MITOGEN used as a noun is very rare.

 Dictionary entry details 

• MITOGEN (noun)

Sense 1

Meaning:

An agent that triggers mitosis

Classified under:

Nouns denoting substances

Hypernyms ("mitogen" is a kind of...):

agent (a substance that exerts some force or effect)

 Context examples 

Concanavalin A is a potent lymphocyte mitogen and a stimulator of matrix metalloproteinases, thereby exhibiting immunostimulatory effects.

(Concanavalin A, NCI Thesaurus)

It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF.

(Diphtheria Toxin Receptor, NCI Thesaurus)

Betacellulin is a member of the EGF family of growth factors; a potent mitogen for retinal pigment epithelia and vascular smooth muscle cells.

(Betacellulin, NCI Thesaurus)

This gene plays a role in signal transduction and the cellular response to mitogens.

(ARAF Gene, NCI Thesaurus)

This allele, which encodes connective tissue growth factor protein, is involved in mitogen stimulation and cellular growth signal transduction through the TGFbeta/Smad signaling pathway.

(CTGF wt Allele, NCI Thesaurus)

Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in cancer cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.

(Bufalin, NCI Thesaurus)

Upon administration, anti-HLA-DR monoclonal antibody IMMU-114 binds to HLA-DR on HLA-DR-expressing tumor cells and, although the exact mechanism has yet to be fully elucidated, appears to induce hyperactivation of ERK- and JNK-dependent mitogen activated protein kinase signaling pathways.

(Anti-HLA-DR Monoclonal Antibody IMMU-114, NCI Thesaurus)