METHOTREXATE

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does methotrexate mean? 

• METHOTREXATE (noun)
  The noun METHOTREXATE has 1 sense:

1. toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis

  Familiarity information: METHOTREXATE used as a noun is very rare.

 Dictionary entry details 

• METHOTREXATE (noun)

Sense 1

Meaning:

Toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis

Classified under:

Nouns denoting man-made objects

Synonyms:

amethopterin; methotrexate; methotrexate sodium

Hypernyms ("methotrexate" is a kind of...):

antimetabolite (an antineoplastic drug that inhibits the utilization of a metabolite)

immune suppressant drug; immunosuppressant; immunosuppressive; immunosuppressive drug; immunosuppressor (a drug that lowers the body's normal immune response)

 Context examples 

A teratogenic disorder observed in a newborn or child of a mother who was exposed to methotrexate during pregnancy.

(Fetal Methotrexate Syndrome, NCI Thesaurus)

The active ingredient in a drug used to lessen the toxic effects of substances that block the action of folic acid, especially the anticancer drug methotrexate.

(Folinic acid, NCI Dictionary)

A regimen consisting of fluorouracil, doxorubicin and methotrexate used for the treatment of advanced-stage gastric cancer.

(FAMTX Regimen, NCI Thesaurus)

A chemotherapy regimen consisting of 5-fluorouracil, methotrexate with leucovorin rescue, cytarabine, cyclophosphamide, doxorubicin, vincristine, and prednisone.

(F-MACHOP Regimen, NCI Thesaurus)

A chemotherapy combination consisting of cyclophosphamide, doxorubicin, etoposide, mechlorethamine, methotrexate, prednisone, procarbazine, and vincristine.

(Cyclophosphamide/Doxorubicin/Etoposide/Mechlorethamine/Methotrexate/Prednisone/Procarbazine/Vincristine, NCI Thesaurus)

EXAMPLE(S): Administration of methotrexate as part of chemotherapy.

(Defined Substance Administration, NCI Thesaurus/BRIDG)

A bacterial enzyme that breaks down proteins and other substances, including methotrexate.

(Glucarpidase, NCI Dictionary)

Methotrexate stops cells from making DNA and may kill cancer cells.

(Methotrexate, NCI Dictionary)

A regimen consisting of ifosfamide, cisplatin and high-dose methotrexate, used for the treatment of metastatic childhood osteosarcoma.

(OS-86 Regimen, NCI Thesaurus)

EXAMPLE(S): An experimental unit who receives methotrexate as part of chemotherapy, radiation therapy.

(Performed Substance Administration, NCI Thesaurus/BRIDG)