English Dictionary

MEFLOQUINE

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 Dictionary entry overview: What does mefloquine mean? 

MEFLOQUINE (noun)
  The noun MEFLOQUINE has 1 sense:

1. an antimalarial drug (trade name Larium and Mephaquine) that is effective in cases that do not respond to chloroquine; said to produce harmful neuropsychiatric effects on some peopleplay

  Familiarity information: MEFLOQUINE used as a noun is very rare.


 Dictionary entry details 


MEFLOQUINE (noun)


Sense 1

Meaning:

An antimalarial drug (trade name Larium and Mephaquine) that is effective in cases that do not respond to chloroquine; said to produce harmful neuropsychiatric effects on some people

Classified under:

Nouns denoting man-made objects

Synonyms:

Larium; mefloquine; mefloquine hydrochloride; Mephaquine

Hypernyms ("mefloquine" is a kind of...):

antimalarial; antimalarial drug (a medicinal drug used to prevent or treat malaria)


 Context examples 


Mefloquine hydrochloride is active against Plasmodium falciparum and Plasmodium vivax.

(Mefloquine Hydrochloride, NCI Thesaurus)

Although the exact mechanism remains to be elucidated, mefloquine, a weak base, preferentially accumulates in lysosomes and disrupts lysosomal function and integrity, thereby leading to host cell death.

(Mefloquine, NCI Thesaurus)

The hydrochloride salt form of mefloquine, a piperidinyl quinidine with antimalarial activity.

(Mefloquine Hydrochloride, NCI Thesaurus)

Compared to chloroquine, mefloquine has better blood-brain-barrier (BBB) penetration.

(Mefloquine, NCI Thesaurus)

Although the exact mechanism of mefloquine hydrochloride is largely unknown, this agent acts as a blood schizonticide and probably exert its actions by interacting with the phospholipid bilayer, thereby interfering with the stability of the cell membrane and causing cell lysis.

(Mefloquine Hydrochloride, NCI Thesaurus)



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