MEDIATE

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does mediate mean? 

• MEDIATE (adjective)
  The adjective MEDIATE has 2 senses:

1. acting through or dependent on an intervening agency

2. being neither at the beginning nor at the end in a series

  Familiarity information: MEDIATE used as an adjective is rare.

• MEDIATE (verb)
  The verb MEDIATE has 2 senses:

1. act between parties with a view to reconciling differences

2. occupy an intermediate or middle position or form a connecting link or stage between two others

  Familiarity information: MEDIATE used as a verb is rare.

 Dictionary entry details 

• MEDIATE (adjective)

Sense 1

Meaning:

Acting through or dependent on an intervening agency

Context example:

the disease spread by mediate as well as direct contact

Similar:

indirect (having intervening factors or persons or influences)

mediated (acting or brought about through an intervening agency)

Attribute:

immediacy; immediateness (lack of an intervening or mediating agency)

Antonym:

immediate (having no intervening medium)

Derivation:

mediateness (the quality of being mediate)

Sense 2

Meaning:

Being neither at the beginning nor at the end in a series

Synonyms:

in-between; mediate; middle

Context example:

the middle point on a line

Similar:

intermediate (lying between two extremes in time or space or state)

• MEDIATE (verb)

Present simple: I / you / we / they mediate    ... he / she / it mediates   
Past simple: mediated   
Past participle: mediated   
-ing form: mediating   

Sense 1

Meaning:

Act between parties with a view to reconciling differences

Classified under:

Verbs of telling, asking, ordering, singing

Synonyms:

arbitrate; intercede; intermediate; liaise; mediate

Context example:

He mediated a settlement

Hypernyms (to "mediate" is one way to...):

negociate; negotiate; talk terms (discuss the terms of an arrangement)

Sentence frames:

Somebody ----s
Somebody ----s PP

Sentence example:

Sam and Sue mediate

Derivation:

mediation (the act of intervening for the purpose of bringing about a settlement)

mediation (a negotiation to resolve differences that is conducted by some impartial party)

mediator (a negotiator who acts as a link between parties)

Sense 2

Meaning:

Occupy an intermediate or middle position or form a connecting link or stage between two others

Classified under:

Verbs of being, having, spatial relations

Context example:

mediate between the old and the new

Hypernyms (to "mediate" is one way to...):

lie (be located or situated somewhere; occupy a certain position)

Sentence frame:

Something ----s

 Context examples 

These regenerative effects may be mediated through stem cells, but a direct link between laser treatment and stem cell biology hadn’t been clearly demonstrated.

(Laser Therapy Prompts Regeneration in Teeth, NIH)

Schwannomin and HRS co-localize at endosomes suggesting that schwannomin is involved in HRS-mediated cell signaling.

(Merlin, NCI Thesaurus)

MET inhibitor EMD 1204831 selectively binds to Met tyrosine kinase, thereby disrupting MET mediated signal transduction pathways.

(MET Tyrosine Kinase Inhibitor EMD 1204831, NCI Thesaurus)

Upon intravenous administration, c-Met inhibitor SAR125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways.

(MET Tyrosine Kinase Inhibitor SAR125844, NCI Thesaurus)

Once the team identified these “candidate” genes, they sought additional evidence that these genes play a role in susceptibility to T cell-mediated killing.

(A new study identifies essential genes for cancer immunotherapy, National Institutes of Health)

This protein plays a role in both proteolysis and integrin-mediated signaling.

(A Disintegrin and Metalloprotease with Thrombospondin Motifs 1, NCI Thesaurus)

Usually, it is a result of cAMP-mediated triggered activity and typically originates from the right ventricular outflow tract.

(Adenosine-Sensitive Ventricular Tachycardia by ECG Finding, NCI Thesaurus)

AP1903 binds to the drug binding domain, leading to iMC oligomerization and activation of iCD40 and MyD88-mediated signaling in iMC-expressing DCs.

(Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201, NCI Thesaurus)

This results in the immune-mediated inhibition of tumor cell proliferation, and leads to tumor death.

(Adenovirus 5-Human Guanylyl Cyclase C-PADRE Vaccine, NCI Thesaurus)

The monomer form of this agent has relaxation effect on smooth muscle systemically, which might be a result of nitric oxide-mediated response.

(Methyl Methacrylate, NCI Thesaurus)