English Dictionary

LEFLUNOMIDE

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 Dictionary entry overview: What does leflunomide mean? 

LEFLUNOMIDE (noun)
  The noun LEFLUNOMIDE has 1 sense:

1. an anti-TNF compound (trade name Arava) that is given orally; can slow the progression of rheumatoid arthritis by slowing the proliferation of white blood cells which reduces inflammation in the synoviumplay

  Familiarity information: LEFLUNOMIDE used as a noun is very rare.


 Dictionary entry details 


LEFLUNOMIDE (noun)


Sense 1

Meaning:

An anti-TNF compound (trade name Arava) that is given orally; can slow the progression of rheumatoid arthritis by slowing the proliferation of white blood cells which reduces inflammation in the synovium

Classified under:

Nouns denoting man-made objects

Synonyms:

Arava; leflunomide

Hypernyms ("leflunomide" is a kind of...):

anti-TNF compound (a class of drugs that block the action of tumor necrosis factor (TNF); used in cases of rheumatoid arthritis because TNF instigates inflammation of the joints)


 Context examples 


As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes.

(Leflunomide, NCI Thesaurus)



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