KINETOCHORE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does kinetochore mean? 

• KINETOCHORE (noun)
  The noun KINETOCHORE has 1 sense:

1. a specialized condensed region of each chromosome that appears during mitosis where the chromatids are held together to form an X shape

  Familiarity information: KINETOCHORE used as a noun is very rare.

 Dictionary entry details 

• KINETOCHORE (noun)

Sense 1

Meaning:

A specialized condensed region of each chromosome that appears during mitosis where the chromatids are held together to form an X shape

Classified under:

Nouns denoting body parts

Synonyms:

centromere; kinetochore

Context example:

the centromere is difficult to sequence

Hypernyms ("kinetochore" is a kind of...):

anatomical structure; bodily structure; body structure; complex body part; structure (a particular complex anatomical part of a living thing and its construction and arrangement)

Holonyms ("kinetochore" is a part of...):

chromosome (a threadlike strand of DNA in the cell nucleus that carries the genes in a linear order)

 Context examples 

The proteins responsible for this form a complex on the kinetochores.

(Mitotic/Spindle Checkpoint, NCI Thesaurus)

This protein plays a role in cell cycle progression and is required for both kinetochore formation and chromosome segregation during mitosis.

(Centromere Protein F, NCI Thesaurus)

This allele, which encodes CENP-F kinetochore protein, plays a role in mitotic chromosomal segregation.

(CENPF wt Allele, NCI Thesaurus)

During mitosis, APC localizes to microtubule ends within kinetochores forming a complex with BUB1 and BUB3 checkpoint proteins.

(Adenomatous Polyposis Coli Protein, NCI Thesaurus)

APC mutant cells form mitotic spindles with microtubules that ineffectively connect with kinetochores, leading to chromosomal instability and defective chromosome segregation.

(Adenomatous Polyposis Coli Protein, NCI Thesaurus)