IRREPARABLE

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 Dictionary entry overview: What does irreparable mean? 

• IRREPARABLE (adjective)
  The adjective IRREPARABLE has 1 sense:

1. impossible to repair, rectify, or amend

  Familiarity information: IRREPARABLE used as an adjective is very rare.

 Dictionary entry details 

• IRREPARABLE (adjective)

Sense 1

Meaning:

Impossible to repair, rectify, or amend

Context example:

irreparable damages

Antonym:

reparable (capable of being repaired or rectified)

 Context examples 

As the stabilized active metabolite of ifosfamide, palifosfamide irreversibly alkylates and crosslinks DNA through GC base pairs, resulting in irreparable 7-atom interstrand crosslinks.

(Palifosfamide Tromethamine, NCI Thesaurus)

“I can offer you no consolation, my friend,” said he; “your disaster is irreparable. What do you intend to do?”

(Frankenstein, by Mary Wollstonecraft Shelley)

Mr. Mell having left me while he took his irreparable boots upstairs, I went softly to the upper end of the room, observing all this as I crept along.

(David Copperfield, by Charles Dickens)

Nearly all of them were totally ruined—an irreparable loss.

(The Lost World, by Sir Arthur Conan Doyle)

An active metabolite of ifosfamide covalently linked to the amino acid lysine for stability, palifosfamide irreversibly alkylates and cross-links DNA through GC base pairs, resulting in irreparable 7-atom inter-strand cross-links; inhibition of DNA replication and cell death follow.

(Palifosfamide, NCI Thesaurus)

The G1/S checkpoint process selectively induces cell cycle arrest in cancer cells with irreparable DNA damages and triggers subsequent apoptosis, while allowing cell division to proceed in cells without or with minor reparable DNA damage.

(E2F1 Pathway Activator ARQ 171, NCI Thesaurus)

In transfected tumor cells, the wild-type p-53 gene product exerts an antitumor effect by blocking cell cycle progression at the G1/S regulation point, activating DNA repair proteins in the presence of DNA damage, and initiating apoptosis when DNA damage is irreparable.

(Ad5CMV-p53 Gene, NCI Thesaurus)

Her thoughts were silently fixed on the irreparable injury which too early an independence and its consequent habits of idleness, dissipation, and luxury, had made in the mind, the character, the happiness, of a man who, to every advantage of person and talents, united a disposition naturally open and honest, and a feeling, affectionate temper.

(Sense and Sensibility, by Jane Austen)

For that reason I turned away from you this evening when you upset my books, for I was in danger at the time, and any show of surprise and emotion upon your part might have drawn attention to my identity and led to the most deplorable and irreparable results.

(The Return of Sherlock Holmes, by Sir Arthur Conan Doyle)

I need not describe the feelings of those whose dearest ties are rent by that most irreparable evil, the void that presents itself to the soul, and the despair that is exhibited on the countenance.

(Frankenstein, by Mary Wollstonecraft Shelley)