GUANINE

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does guanine mean? 

• GUANINE (noun)
  The noun GUANINE has 1 sense:

1. a purine base found in DNA and RNA; pairs with cytosine

  Familiarity information: GUANINE used as a noun is very rare.

 Dictionary entry details 

• GUANINE (noun)

Sense 1

Meaning:

A purine base found in DNA and RNA; pairs with cytosine

Classified under:

Nouns denoting substances

Synonyms:

G; guanine

Hypernyms ("guanine" is a kind of...):

purine (any of several bases that are derivatives of purine)

Holonyms ("guanine" is a substance of...):

deoxyribonucleic acid; desoxyribonucleic acid; DNA ((biochemistry) a long linear polymer found in the nucleus of a cell and formed from nucleotides and shaped like a double helix; associated with the transmission of genetic information)

ribonucleic acid; RNA ((biochemistry) a long linear polymer of nucleotides found in the nucleus but mainly in the cytoplasm of a cell where it is associated with microsomes; it transmits genetic information from DNA to the cytoplasm and controls certain chemical processes in the cell)

 Context examples 

Relative to other cell types, lypmocytes are highly dependent on salvage and de novo synthesis of guanine nucleotides, thus making these cells prone to MPA cytotoxicity.

(Mycophenolate Sodium, NCI Thesaurus)

Dacplatinum alkylates DNA at the N-7 position of guanine, thereby producing DNA interstrand crosslinks and DNA strand breaks, and inhibiting DNA replication.

(Dacplatinum, NCI Thesaurus)

A pyrimidine base found in DNA and RNA that pairs with guanine.

(Cytosine, NCI Thesaurus)

K-Ras is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein.

(Oncogene K-Ras, NCI Thesaurus)

A guanine analogue with antineoplastic activity.

(O6-Benzylguanine, NCI Thesaurus)

MPA displays high lymphocyte specificity and cytotoxicity due to the higher dependence of activated lymphocytes on both salvage and de novo synthesis of guanine nucleotides relative to other cell types.

(Mycophenolate mofetil, NCI Thesaurus)

By competing with guanine, dezaguanine gets incorporated into DNA and inhibits DNA synthesis, thereby inducing cell death.

(Dezaguanine Mesylate, NCI Thesaurus)

MPA displays high lymphocyte specificity and cytotoxicity because lymphocyte metabolism is highly dependent on both salvage and de novo synthesis of guanine nucleotides.

(Mycophenolate, NCI Thesaurus)

DNA is a long molecule made by stringing 4 chemical bases together: adenine (A), guanine (G), cytosine (C), and thymine (T).

(Expanding the Genetic Alphabet, NIH)

Upon intravenous administration of 4-demethylcholesteryloxycarbonylpenclomedine, the carbonium moiety binds to and alkylates DNA at the N7 guanine position, thereby causing DNA crosslinks.

(DM-CHOC-PEN, NCI Thesaurus)