EPITOPE

Pronunciation (US):

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IPA (US):

 Dictionary entry overview: What does epitope mean? 

• EPITOPE (noun)
  The noun EPITOPE has 1 sense:

1. the site on the surface of an antigen molecule to which an antibody attaches itself

  Familiarity information: EPITOPE used as a noun is very rare.

 Dictionary entry details 

• EPITOPE (noun)

Sense 1

Meaning:

The site on the surface of an antigen molecule to which an antibody attaches itself

Classified under:

Nouns denoting substances

Synonyms:

antigenic determinant; determinant; epitope

Hypernyms ("epitope" is a kind of...):

site; situation (physical position in relation to the surroundings)

Domain category:

immunology (the branch of medical science that studies the body's immune system)

Holonyms ("epitope" is a part of...):

antigen (any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies))

 Context examples 

Vaccination with anti-Id 11D10 induces anti-anti-idiotype antibodies (Ab3) that may react with breast cancer cell lines expressing the HMFG membrane epitope.

(Monoclonal Antibody 11D10, NCI Thesaurus)

A vaccine consisting of a monoclonal antibody (MoAb) directed against an idiotype that mimics a human milk fat globule (HMFG) membrane epitope.

(Monoclonal Antibody 11D10 Anti-Idiotype Vaccine, NCI Thesaurus)

Monoclonal Antibody 45-2D9 also recognizes this epitope on certain human tumor cells.

(Monoclonal Antibody 45-2D9, NCI Thesaurus)

A mixture of two recombinant IgG1 antibodies directed against different epitopes in the epidermal growth factor receptor (EGFR) extracellular domain III, with potential antineoplastic activity.

(Anti-EGFR Monoclonal Antibody Mixture Sym004, NCI Thesaurus)

A synthetic antibody produced by a genetically homogenous population of hybrid cells (hybridoma) against determinant idiotypes (Id) which usually mimic human epitopes.

(Anti-Idiotype Specified Monoclonal Antibody, NCI Thesaurus)

A recombinant, human monoclonal antibody targeting an extracellular epitope of human prostate specific membrane antigen (PSMA) that is conjugated with a fluorescent dye A488, with potential imaging activity.

(Anti-PSMA Monoclonal Antibody MDX1201-A488, NCI Thesaurus)

MoAb 8.2 is a monoclonal IgG1 antibody that recognizes an epitope near the amino-terminal portion of p97.

(Monoclonal Antibody 8.2, NCI Thesaurus)

MoAb 96.5 is a monoclonal IgG2a antibody that recognizes an epitope near the amino-terminal portion of p97.

(Monoclonal Antibody 96.5, NCI Thesaurus)

A peptide cancer vaccine consisting of a combination of peptides derived form several melanoma epitopes.

(Multi-epitope Melanoma Peptide Vaccine, NCI Thesaurus)

A peptide-based melanoma cancer vaccine consisting of neoantigens and peptides derived from patient-specific melanoma immunogenic epitopes, combined with the immunostimulant poly-ICLC with potential immunomodulating and antineoplastic activities.

(Neoantigen-based Melanoma-Poly-ICLC Vaccine, NCI Thesaurus)