ENDONUCLEASE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does endonuclease mean? 

• ENDONUCLEASE (noun)
  The noun ENDONUCLEASE has 1 sense:

1. a nuclease that cleaves nucleic acids at interior bonds and so produces fragments of various sizes

  Familiarity information: ENDONUCLEASE used as a noun is very rare.

 Dictionary entry details 

• ENDONUCLEASE (noun)

Sense 1

Meaning:

A nuclease that cleaves nucleic acids at interior bonds and so produces fragments of various sizes

Classified under:

Nouns denoting substances

Hypernyms ("endonuclease" is a kind of...):

nuclease (general term for enzymes that catalyze the hydrolysis of nucleic acid by cleaving chains of nucleotides into smaller units)

Hyponyms (each of the following is a kind of "endonuclease"):

restriction endonuclease; restriction enzyme; restriction nuclease (any of the enzymes that cut nucleic acid at specific restriction sites and produce restriction fragments; obtained from bacteria (where they cripple viral invaders); used in recombinant DNA technology)

 Context examples 

An orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APEX1 or APE1), with anti-schistosomal and potential antineoplastic activity.

(Lucanthone, NCI Thesaurus)

Ionomycin is a calcium ionophore that increases intracellular Ca++ levels, possibly relating to endonuclease activation of lymphocytes and decreased ratio of Bcl-2 to Bax and ultimately apoptosis.

(Ionomycin, NCI Thesaurus)

Flap endonuclease 1 (380 aa, ~43 kDa) is encoded by the human FEN1 gene.

(Flap Endonuclease 1, NCI Thesaurus)

This allele, which encodes flap endonuclease 1 protein, plays a role in the mediation of DNA repair.

(FEN1 wt Allele, NCI Thesaurus)

Mismatch repair endonuclease PMS2 (862 aa, ~96 kDa) is encoded by the human PMS2 gene.

(Mismatch Repair Endonuclease PMS2, NCI Thesaurus)

This allele, which encodes endonuclease III-like protein 1, is involved in DNA repair by nucleotide-excision.

(NTHL1 wt Allele, NCI Thesaurus)

This allele, which encodes endonuclease 8-like 3 protein, is involved in DNA binding and repair.

(NEIL3 wt Allele, NCI Thesaurus)

This complex possesses manganese-dependent single-stranded DNA endonuclease and 3-prime to 5-prime exonuclease activities.

(MRE11/RAD50 Double-Strand Break Repair Complex, NCI Thesaurus/from OMIM)

This allele, which encodes DNA repair endonuclease XPF protein, is involved in nucleotide excision repair.

(ERCC4 wt Allele, NCI Thesaurus)

Endonuclease III-like protein 1 (312 aa, ~34 kDa) is encoded by the human NTHL1 gene.

(Endonuclease III-Like Protein 1, NCI Thesaurus)