DIOL

Pronunciation (US):

(GB):

 Dictionary entry overview: What does diol mean? 

• DIOL (noun)
  The noun DIOL has 1 sense:

1. any of a class of alcohols having 2 hydroxyl groups in each molecule

  Familiarity information: DIOL used as a noun is very rare.

 Dictionary entry details 

• DIOL (noun)

Sense 1

Meaning:

Any of a class of alcohols having 2 hydroxyl groups in each molecule

Classified under:

Nouns denoting substances

Synonyms:

dihydric alcohol; diol; glycol

Hypernyms ("diol" is a kind of...):

alcohol (any of a series of volatile hydroxyl compounds that are made from hydrocarbons by distillation)

 Context examples 

PAH causes a carcinogenic effect by metabolic activation to diol epoxides, which bind covalently to DNA.

(Carcinogenic Polycyclic Aromatic Hydrocarbon, NCI Thesaurus)

Benzo(a)pyrene-trans-7,8-dihydrodiol is an intermediate in the conversion of benzo(a)pyrene to the highly potent mutagen and carcinogen benzopyrene diol epoxide via cytochrome P450 CYP1A1.

(Benzo[a]pyrene trans-7,8-Dihydrodiol, NCI Thesaurus)

A noncarcinogenic and structural analogue of polycyclic aromatic hydrocarbon (PAH), phenanthrene labeled with deuterium ([D10]Phe) with potential use in assessing an individual's capacity for PAH metabolism by the diol epoxide pathway.

(Deuterated Phenanthrene, NCI Thesaurus)

The metabolites of DL-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes.

(Limonene, (+/-)-, NCI Thesaurus)

Although the mechanism of action has yet to be fully elucidated, limonene and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and may induce apoptosis via the induction of the transforming growth factor beta-signaling pathway.

(Limonene, NCI Thesaurus)

Upon oral or inhalation administration, [D10]Phe is metabolized into the tetraol end product ([D10]PheT) via the diol epoxide pathway, and can be quantified in urine. [D10]PheT can be used as a biomarker to assess PAHs metabolic activation and may therefore determine an individual's susceptibility to carcinogenicity upon PAH exposure.

(Deuterated Phenanthrene, NCI Thesaurus)