DESTABILIZE

Pronunciation (US):

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IPA (US):

 Dictionary entry overview: What does destabilize mean? 

• DESTABILIZE (verb)
  The verb DESTABILIZE has 2 senses:

1. become unstable

2. make unstable

  Familiarity information: DESTABILIZE used as a verb is rare.

 Dictionary entry details 

• DESTABILIZE (verb)

Present simple: I / you / we / they destabilize    ... he / she / it destabilizes   
Past simple: destabilized   
Past participle: destabilized   
-ing form: destabilizing   

Sense 1

Meaning:

Become unstable

Classified under:

Verbs of size, temperature change, intensifying, etc.

Synonyms:

destabilise; destabilize

Context example:

The economy destabilized rapidly

Hypernyms (to "destabilize" is one way to...):

change (undergo a change; become different in essence; losing one's or its original nature)

Sentence frames:

Something ----s
Somebody ----s

Antonym:

stabilize (become stable or more stable)

Derivation:

destabilization (the action of destabilizing; making something less stable (especially of a government or country or economy))

Sense 2

Meaning:

Make unstable

Classified under:

Verbs of size, temperature change, intensifying, etc.

Synonyms:

destabilise; destabilize

Context example:

Terrorism destabilized the government

Hypernyms (to "destabilize" is one way to...):

alter; change; modify (cause to change; make different; cause a transformation)

Sentence frames:

Somebody ----s something
Something ----s something

Antonym:

stabilize (make stable and keep from fluctuating or put into an equilibrium)

Derivation:

destabilization (the action of destabilizing; making something less stable (especially of a government or country or economy))

destabilization (an event that causes a loss of equilibrium (as of a ship or aircraft))

 Context examples 

In addition, mHtt affects Ca2+ signaling by sensitizing InsP3R1 to activation by InsP3, stimulating NR2B/NR1 NMDAR activity, and destabilizing mitochondrial Ca2+ handling.

(Huntington's Disease Pathway, NCI Thesaurus/KEGG)

Indibulin binds to a site on tubulin that is different from taxane- or Vinca alkaloid-binding sites, destabilizing tubulin polymerization and inducing tumor cell cycle arrest and apoptosis.

(Indibulin, NCI Thesaurus)

This prevents nucleolin from binding to and stabilizing mRNA of the anti-apoptotic Bcl2; destabilizing Bcl2 mRNA leads to a reduction in Bcl2 protein synthesis and induces apoptosis.

(Nucleolin Antagonist IPP-204106N, NCI Thesaurus)

Encoded by human HNRPA3 Gene, 379-amino acid 40-kD Heterogeneous Nuclear Ribonucleoprotein A3 is similar to helix destabilizing heterogeneous nuclear ribonucleoprotein A1 (rat) and to heterogeneous ribonucleoproteins (putative components of ribonucleosomes).

(Heterogeneous Nuclear Ribonucleoprotein A3, NCI Thesaurus)

Hsp inhibitors may destabilize, and facilitate degradation of proto-oncoproteins leading to reversal of apoptosis regulation and cell death.

(Heat Shock Protein Inhibitor, NCI Thesaurus)

TTP binds to these molecules and destabilizes them, resulting in lower levels of cytokines and, thus, decreased inflammation.

(Natural protein points to new inflammation treatment, NIH)

A folate receptor-targeting cytotoxic drug conjugate consisting of a folate vitamin analogue linked to a vinca alkaloid microtubule destabilizing agent with potential antineoplastic activity.

(Folate Receptor-Targeted Vinca Alkaloid EC0489, NCI Thesaurus)

Upon administration of BAL101553 and conversion into the active form BAL27862, this agent binds to tubulin at a site distinct from the vinca-alkaloid-binding site, and prevents tubulin polymerization and destabilizes microtubules, ultimately leading to cell cycle arrest, blockage of cell division and an induction of cell death in cancer cells.

(Microtubule-targeted Agent BAL101553, NCI Thesaurus)

Via binding to cell surface nucleolin, AS1411 is internalized and may prevent nucleolin from binding to and stabilizing mRNA of the anti-apoptotic BCL2, thereby destabilizing BCL2 mRNA, leading to a reduction in BCL2 protein synthesis.

(Anti-Nucleolin Aptamer AS1411, NCI Thesaurus)

The researchers found cavities that undercut the base of these leading edges that can destabilize the ice front and enhance iceberg calving, the process where parts of the glacier break off and float away.

(The Hidden Meltdown of Greenland, NASA)