DESENSITIZATION

Pronunciation (US):

(GB):

 Dictionary entry overview: What does desensitization mean? 

• DESENSITIZATION (noun)
  The noun DESENSITIZATION has 1 sense:

1. the process of reducing sensitivity

  Familiarity information: DESENSITIZATION used as a noun is very rare.

 Dictionary entry details 

• DESENSITIZATION (noun)

Sense 1

Meaning:

The process of reducing sensitivity

Classified under:

Nouns denoting natural processes

Synonyms:

desensitisation; desensitization

Context example:

the patient was desensitized to the allergen

Hypernyms ("desensitization" is a kind of...):

decrease; decrement (a process of becoming smaller or shorter)

Derivation:

desensitize (make insensitive)

desensitize (cause not to be sensitive)

 Context examples 

Desensitization of GPCRs occurs through protein kinases that phosphorylate the GPCR to turn off signaling.

(Attenuation of GPCR Signaling Pathway, NCI Thesaurus/BIOCARTA)

ADRBK2 regulates desensitization of G protein-coupled receptors.

(Beta-Adrenergic Receptor Kinase 2, NCI Thesaurus)

The findings suggest the potential benefits of using omalizumab to safely and rapidly facilitate desensitization to multiple food allergens.

(Omalizumab improves efficacy of oral immunotherapy for multiple food allergies, National Institutes of Health)

This may take place either through receptor internalization and/or through receptor desensitization.

(Long-Term Depression Pathway, NCI Thesaurus/KEGG)

In addition, this agent is capable of inhibiting rapid desensitization of the ionotropic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors, thereby potentiating glutamate responses which may induce seizures activity.

(Cyclothiazide, NCI Thesaurus)

This allele, which encodes beta-arrestin-1 protein, plays a role in the desensitization of beta-adrenergic receptor signaling.

(ARRB1 wt Allele, NCI Thesaurus)

This modification results in mediation of agonist-specific desensitization observed at high agonist concentrations.

(ADRBK1 wt Allele, NCI Thesaurus)

Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness.

(Paroxetine hydrochloride, NCI Thesaurus)

A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.

(Diabetes mellitus, NCI Thesaurus)

Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, which resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness.

(Paroxetine Mesylate, NCI Thesaurus)