DEPLETE

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does deplete mean? 

• DEPLETE (verb)
  The verb DEPLETE has 1 sense:

1. use up (resources or materials)

  Familiarity information: DEPLETE used as a verb is very rare.

 Dictionary entry details 

• DEPLETE (verb)

Present simple: I / you / we / they deplete    ... he / she / it depletes   
Past simple: depleted   
Past participle: depleted   
-ing form: depleting   

Sense 1

Meaning:

Use up (resources or materials)

Classified under:

Verbs of eating and drinking

Synonyms:

consume; deplete; eat; eat up; exhaust; run through; use up; wipe out

Context example:

They run through 20 bottles of wine a week

Hypernyms (to "deplete" is one way to...):

drop; expend; spend (pay out)

Verb group:

occupy; take; use up (require (time or space))

Troponyms (each of the following is one way to "deplete"):

run out (exhaust the supply of)

drain (deplete of resources)

indulge; luxuriate (enjoy to excess)

burn; burn off; burn up (use up (energy))

spend (spend completely)

exhaust; play out; run down; sap; tire (deplete)

Sentence frames:

Somebody ----s something
Something ----s something

Sentence example:

They deplete him of all his money

Derivation:

depletion (the act of decreasing something markedly)

depletion (the state of being depleted)

 Context examples 

Buthionine sulfoximine irreversibly inhibits gamma-glutamylcysteine synthase, thereby depleting cells of glutathione, a metabolite that plays a critical role in protecting cells against oxidative stress, and resulting in free radical-induced apoptosis.

(Buthionine sulfoximine, NCI Thesaurus)

A monoclonal antibody directed against the receptor-like leukocyte cell surface glycoprotein CD45 with leukocyte-depleting activity.

(anti-CD45 monoclonal antibody, NCI Thesaurus)

A proprietary antibody-based single-chain polypeptide with B cell-depleting activity.

(CD20-targeted Polypeptide TRU-015, NCI Thesaurus)

Lymphocyte depleted Hodgkin lymphoma occurring in childhood.

(Childhood Lymphocyte Depleted Classical Hodgkin Lymphoma, NCI Thesaurus)

Anti-CD19 monoclonal antibody MDX-1342 binds to CD19, depleting and eliminating CD19-expressing B-cells.

(Anti-CD19 Monoclonal Antibody MDX-1342, NCI Thesaurus)

Annonaceous acetogenins, derivatives of long-chain fatty acids, exhibit their anti-tumor properties by depleting cellular stores of adenosine 5'-triphosphate (ATP), a primary source of energy in cells.

(Annona muricata, NCI Thesaurus)

The scientists depleted the microglia in the retinas of mice using the drug PLX5622, which blocks the microglial CSF-1 receptor.

(Immune cells in the retina can spontaneously regenerate, National Institutes of Health)

Depleting CD8+ T cells or neutralizing IL-17A removed this protective effect.

(Skin Microbes and the Immune Response, NIH)

A lymphocyte depleted Hodgkin lymphoma occurring in adults.

(Adult Lymphocyte Depleted Classical Hodgkin Lymphoma, NCI Thesaurus)

Most cases are morphologically classified as lymphocyte depleted or mixed cellularity Hodgkin lymphomas.

(AIDS-Related Hodgkin Lymphoma, NCI Thesaurus)