COX-1

 Dictionary entry overview: What does Cox-1 mean? 

• COX-1 (noun)
  The noun COX-1 has 1 sense:

1. an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys

  Familiarity information: COX-1 used as a noun is very rare.

 Dictionary entry details 

• COX-1 (noun)

Sense 1

Meaning:

An enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys

Classified under:

Nouns denoting substances

Synonyms:

Cox-1; cyclooxygenase-1

Context example:

an unfortunate side effect of NSAIDs is that they block Cox-1

Hypernyms ("Cox-1" is a kind of...):

Cox; cyclooxygenase (either of two related enzymes that control the production of prostaglandins and are blocked by aspirin)

 Context examples 

Thromboxane is a potent vasoconstrictor and platelet activator, so inhibition of Cox-1 in platelets by aspirin may explain some of the cardioprotective actions of aspirin.

(Aspirin Inhibition of Platelet Activation Pathway, NCI Thesaurus/BIOCARTA)

PGH2 synthase actually consists of two enzyme components, a cyclooxygenase and a peroxidase, and there are more than one type of cyclooxygenase, including Cox-1 and Cox-2.

(Eicosanoid Metabolism Pathway, NCI Thesaurus/BIOCARTA)

A novel Cox enzyme isoform encoded by the Cox-1 gene, Cox-3, contains an additional 30-34 amino acids and is expressed selectively in the brain.

(Acetaminophen Pathway, NCI Thesaurus/BIOCARTA)

Arachidonic acid is converted to the prostaglandin PGG2 by the enzyme Cox-1 in platelets, and Cox-1 is inhibited by aspirin, reducing thromboxane A2 production by platelets.

(Aspirin Inhibition of Platelet Activation Pathway, NCI Thesaurus/BIOCARTA)

Until very recently, only two Cox enzymes, Cox-1 and Cox-2, were known to be targets of NSAIDS.

(Acetaminophen Pathway, NCI Thesaurus/BIOCARTA)

Cox-1 is expressed in a constitutive manner throughout most tissues, and plays an essential role in maintaining the integrity of the stomach mucosal lining.

(Acetaminophen Pathway, NCI Thesaurus/BIOCARTA)

While these two isoforms were sufficient to account for most NSAIDs pharmacology, the actions of acetaminophen remained hard to explain on the basis of inhibiting Cox-1 and Cox-2 alone, such as its efficacy at reducing pain and fever but lack of anti-inflammatory effects.

(Acetaminophen Pathway, NCI Thesaurus/BIOCARTA)