CLOTTING FACTOR

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does clotting factor mean? 

• CLOTTING FACTOR (noun)
  The noun CLOTTING FACTOR has 1 sense:

1. any of the factors in the blood whose actions are essential for blood coagulation

  Familiarity information: CLOTTING FACTOR used as a noun is very rare.

 Dictionary entry details 

• CLOTTING FACTOR (noun)

Sense 1

Meaning:

Any of the factors in the blood whose actions are essential for blood coagulation

Classified under:

Nouns denoting substances

Synonyms:

clotting factor; coagulation factor

Hypernyms ("clotting factor" is a kind of...):

plasma protein (any of the proteins in blood plasma)

Hyponyms (each of the following is a kind of "clotting factor"):

factor I; fibrinogen (a protein present in blood plasma; converts to fibrin when blood clots)

factor II; prothrombin (a protein in blood plasma that is the inactive precursor of thrombin)

factor III; thrombokinase; thromboplastin (an enzyme liberated from blood platelets that converts prothrombin into thrombin as blood starts to clot)

calcium ion; factor IV (ion of calcium; a factor in the clotting of blood)

accelerator factor; factor V; proaccelerin; prothrombin accelerator (a coagulation factor)

cothromboplastin; factor VII; proconvertin; stable factor (a coagulation factor formed in the kidney under the influence of vitamin K)

antihaemophilic factor; antihaemophilic globulin; antihemophilic factor; antihemophilic globulin; factor VIII; Hemofil (a coagulation factor (trade name Hemofil) whose absence is associated with hemophilia A)

Christmas factor; factor IX (coagulation factor whose absence is associated with hemophilia B)

factor X; prothrombinase (coagulation factor that is converted to an enzyme that converts prothrombin to thrombin in a reaction that depends on calcium ions and other coagulation factors)

factor XI; plasma thromboplastin antecedent (coagulation factor whose deficiency results in a hemorrhagic tendency)

factor XII; Hageman factor (coagulation factor whose deficiency results in prolongation of clotting time of venous blood)

factor XIII; fibrinase (in the clotting of blood thrombin catalyzes factor XIII into its active form (fibrinase) which causes fibrin to form a stable clot)

 Context examples 

The main treatment is injecting the missing clotting factor into the bloodstream.

(Hemophilia, NIH: National Heart, Lung, and Blood Institute)

The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin.

(Heparin Calcium, NCI Thesaurus)

MSP is related to clotting factors that are activated by proteolytic cleavage and pro-MSP is itself also activated by cleavage to MSP.

(Macrophage Stimulating 1 Receptor Signaling Pathway, NCI Thesaurus/BIOCARTA)

Clustering Eph kinases or ephrins in platelets stimulated cytoskeletal changes as well as other markers of platelet activation during clotting such as secretion of alpha-granules to release clotting factors.

(Platelet Aggregation Pathway, NCI Thesaurus/BIOCARTA)

A fusion protein of clotting factor VII with the Fc portion of an IgG1 antibody.

(FVII Icon, NCI Thesaurus)

A clotting factor found in the serum.

(Coagulation Factor VII, NCI Thesaurus)

If you have a bleeding disorder, you either do not have enough platelets or clotting factors or they don't work the way they should.

(Bleeding Disorders, NIH)

Anisindione interferes with the vitamin K-dependent hepatic synthesis of active clotting factors by inhibiting the reduction of vitamin K. This leads to an inhibition of gamma-carboxylation of glutamic acid residues to gamma-carboxyglutamic acid in clotting factors II, VII, IX and X. The consequential effects of this inhibition include a reduced activity of these clotting factors and prolonged blood clotting time.

(Anisindione, NCI Thesaurus)

The complex binds to and irreversibly inactivates thrombin and other activated clotting factors, such as factors IX, X, XI, and XII, thereby preventing the polymerization of fibrinogen to fibrin and the subsequent formation of clots.

(Heparin, NCI Thesaurus)

ML-10 appears to mimic the alkyl-malonic acid motif present in gamma -carboxyglutamic (Gla), an amino acid that plays a crucial role in the binding of clotting factors to negatively-charged phospholipids exposed on the surfaces of apoptotic cells.

(Fluorine F-18 ML-10, NCI Thesaurus)