CLEAVABLE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does cleavable mean? 

• CLEAVABLE (adjective)
  The adjective CLEAVABLE has 1 sense:

1. capable of being cleaved

  Familiarity information: CLEAVABLE used as an adjective is very rare.

 Dictionary entry details 

• CLEAVABLE (adjective)

Sense 1

Meaning:

Capable of being cleaved

Similar:

divisible (capable of being or liable to be divided or separated)

 Context examples 

Irinotecan, a semisynthetic derivative of camptothecin, inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death.

(Irinotecan-Eluting Beads, NCI Thesaurus)

This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death.

(Idronoxil, NCI Thesaurus)

Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death.

(Exatecan mesylate, NCI Thesaurus)

Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage.

(Doxorubicin, NCI Thesaurus)

SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death.

(Irinotecan/P-glycoprotein Inhibitor HM30181AK Combination Tablet, NCI Thesaurus)

SN-38 binds to and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication, and apoptosis.

(liposomal SN-38, NCI Thesaurus)

A pegylated liposomal formulation comprised of a lipophilic prodrug of the antineoplastic antibiotic mitomycin C containing a cleavable disulfide bond (PL-MLP), with potential antineoplastic activity.

(Pegylated Liposomal Mitomycin C Lipid-based Prodrug, NCI Thesaurus)

In turn, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex of topoisomerase I and DNA, resulting in DNA breaks.

(Pegylated Liposomal Irinotecan, NCI Thesaurus)

This agent acts without increasing topoisomerase II-DNA covalent cleavable complex formation, as do most topoisomerase inhibitors.

(Mitindomide, NCI Thesaurus)

Its mechanism of action appears to be a novel one, since merbarone does not intercalate DNA nor stabilize DNA-topoisomerase II cleavable complexes.

(Merbarone, NCI Thesaurus)