CITRIC ACID CYCLE

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 Dictionary entry overview: What does citric acid cycle mean? 

• CITRIC ACID CYCLE (noun)
  The noun CITRIC ACID CYCLE has 1 sense:

1. in all plants and animals: a series of enzymatic reactions in mitochondria involving oxidative metabolism of acetyl compounds to produce high-energy phosphate compounds that are the source of cellular energy

  Familiarity information: CITRIC ACID CYCLE used as a noun is very rare.

 Dictionary entry details 

• CITRIC ACID CYCLE (noun)

Sense 1

Meaning:

In all plants and animals: a series of enzymatic reactions in mitochondria involving oxidative metabolism of acetyl compounds to produce high-energy phosphate compounds that are the source of cellular energy

Classified under:

Nouns denoting natural processes

Synonyms:

citric acid cycle; Krebs citric acid cycle; Krebs cycle; tricarboxylic acid cycle

Hypernyms ("citric acid cycle" is a kind of...):

biological process; organic process (a process occurring in living organisms)

Meronyms (parts of "citric acid cycle"):

oxidative phosphorylation (an enzymatic process in cell metabolism that synthesizes ATP from ADP)

Holonyms ("citric acid cycle" is a part of...):

metabolic process; metabolism (the organic processes (in a cell or organism) that are necessary for life)

 Context examples 

Transamination or deamination of glutamate produces a-ketoglutarate which feeds into the citric acid cycle.

(Arginine, Histidine, Glutamate, Glutamine, and Proline Degradation Pathway, NCI Thesaurus/BIOCARTA)

Mitochondria are the principal energy source of the cell and contains the cytochrome enzymes of terminal electron transport and the enzymes of the citric acid cycle, fatty acid oxidation, and oxidative phosphorylation.

(Mitochondrion, NCI Thesaurus)

IDH2, an enzyme in the citric acid cycle, is mutated in a variety of cancers; It initiates and drives cancer growth by blocking differentiation and the production of the oncometabolite 2HG.

(IDH2 Inhibitor AG-221, NCI Thesaurus)

This protein plays a role in the meditation of the citric acid cycle.

(Fumarate Hydratase, Mitochondrial, NCI Thesaurus)

The coenzyme NAD+ plays an essential role in cellular redox reactions, including the redox reaction linking the citric acid cycle and oxidative phosphorylation.

(Daporinad, NCI Thesaurus)

The Gly-rich NAD-Binding Domain (often N-terminal) is often found in metabolic enzymes involved in glycolysis, glyconeogenesis, and the citric acid cycle, such as GAPDH (glyceraldehyde-3-phosphate oxidation and phosphorylation), lactate dehydrogenases (lactate to pyruvate conversion), and malate dehydrogenases (malate to oxaloacetate interconversion).

(NAD-Binding Domain, NCI Thesaurus)