CHLOROQUINE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does chloroquine mean? 

• CHLOROQUINE (noun)
  The noun CHLOROQUINE has 1 sense:

1. an antimalarial drug used to treat malaria and amebic dysentery and systemic lupus erythematosus

  Familiarity information: CHLOROQUINE used as a noun is very rare.

 Dictionary entry details 

• CHLOROQUINE (noun)

Sense 1

Meaning:

An antimalarial drug used to treat malaria and amebic dysentery and systemic lupus erythematosus

Classified under:

Nouns denoting man-made objects

Hypernyms ("chloroquine" is a kind of...):

antimalarial; antimalarial drug (a medicinal drug used to prevent or treat malaria)

 Context examples 

Chloroquine may also interfere with the biosynthesis of nucleic acids.

(Chloroquine Hydrochloride, NCI Thesaurus)

Treatment is the same, with a combination of antimalarials such as chloroquine and primaquine.

(Human malaria spread from monkeys found in Brazil, SciDev.Net)

Compared to chloroquine, mefloquine has better blood-brain-barrier (BBB) penetration.

(Mefloquine, NCI Thesaurus)

The sulfate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties.

(Chloroquine Sulfate, NCI Thesaurus)

The phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties.

(Chloroquine Phosphate, NCI Thesaurus)

The SLC22A1L organic cation transporter protein is localized on the apical surface of renal proximal tubules and appears to confer resistance/transport activity to chloroquine and quinidine-related compounds.

(Organic Cation Transporter-Like 2 Protein, NCI Thesaurus)

Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite.

(Chloroquine, NCI Thesaurus)

Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum.

(Chloroquine Hydrochloride, NCI Thesaurus)

Similar to chloroquine, the chemosensitizing and radiosensitizing activities of this agent may be related to its inhibition of autophagocytosis, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation.

(Mefloquine, NCI Thesaurus)

Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation.

(Chloroquine, NCI Thesaurus)