CHECKPOINT

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 Dictionary entry overview: What does checkpoint mean? 

• CHECKPOINT (noun)
  The noun CHECKPOINT has 1 sense:

1. a place (as at a frontier) where travellers are stopped for inspection and clearance

  Familiarity information: CHECKPOINT used as a noun is very rare.

 Dictionary entry details 

• CHECKPOINT (noun)

Sense 1

Meaning:

A place (as at a frontier) where travellers are stopped for inspection and clearance

Classified under:

Nouns denoting spatial position

Hypernyms ("checkpoint" is a kind of...):

stop (a spot where something halts or pauses)

 Context examples 

Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control and are overexpressed by a wide variety of cancer cell types.

(MEK/Aurora Kinase Inhibitor BI 847325, NCI Thesaurus)

Mitotic checkpoint serine/threonine-protein kinase BUB1 (1085 aa, ~122 kDa) is encoded by the human BUB1 gene.

(Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB1, NCI Thesaurus)

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (1050 aa, ~120 kDa) is encoded by the human BUB1B gene.

(Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB1 Beta, NCI Thesaurus)

The checkpoints help maintain the proper order and timing of cell transition events, especially important for DNA replication and chromosome segregation.

(Cell Cycle Checkpoint, NCI Thesaurus)

This gene is involved in cell cycle checkpoints.

(CDK3 Gene, NCI Thesaurus)

ATRIP is required for ATR function, and removal of ATRIP also leads to a loss of checkpoint control of the cell cycle.

(Cancer Susceptibility Pathway, NCI Thesaurus/BIOCARTA)

Aberrant allelic expression, resulting from different mechanisms, could contribute through an alteration of the spindle checkpoint, to the chromosomal instability observed in cancer.

(CCNB2 wt Allele, NCI Thesaurus)

This allele, which encodes cell division cycle protein 20 homolog protein, is involved in spindle assembly checkpoint and metaphase arrest.

(CDC20 wt Allele, NCI Thesaurus)

Chk1, a protein kinase involved in the DNA damage checkpoint response in fission yeast, has been shown to phosphorylate cdc25 at Ser216 in vitro.

(CDC25 and CHK1 Regulatory Pathway, NCI Thesaurus/BIOCARTA)

Mitotic spindle assembly checkpoint protein MAD2A (205 aa, ~24 kDa) is encoded by the human MAD2L1 gene.

(Mitotic Spindle Assembly Checkpoint Protein MAD2A, NCI Thesaurus)