CAPTOPRIL

Pronunciation (US):

(GB):

 Dictionary entry overview: What does captopril mean? 

• CAPTOPRIL (noun)
  The noun CAPTOPRIL has 1 sense:

1. a drug (trade name Capoten) that blocks the formation of angiotensin in the kidneys resulting in vasodilation; used in the treatment of hypertension and congestive heart failure

  Familiarity information: CAPTOPRIL used as a noun is very rare.

 Dictionary entry details 

• CAPTOPRIL (noun)

Sense 1

Meaning:

A drug (trade name Capoten) that blocks the formation of angiotensin in the kidneys resulting in vasodilation; used in the treatment of hypertension and congestive heart failure

Classified under:

Nouns denoting man-made objects

Synonyms:

Capoten; captopril

Hypernyms ("captopril" is a kind of...):

ACE inhibitor; angiotensin-converting enzyme inhibitor (an antihypertensive drug that blocks the formation of angiotensin II in the kidney, leading to relaxation of the arteries; promotes the excretion of salt and water by inhibiting the activity of the angiotensin converting enzyme; also used to treat congestive heart failure)

 Context examples 

Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis.

(Captopril, NCI Thesaurus)

Captopril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

(Alacepril, NCI Thesaurus)

As a prodrug, alacepril is rapidly metabolized to captopril; captopril competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II.

(Alacepril, NCI Thesaurus)

Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion.

(Captopril, NCI Thesaurus)