CANALICULUS (canaliculi)

Pronunciation (US):

(GB):

Irregular inflected form: canaliculi   

 Dictionary entry overview: What does canaliculus mean? 

• CANALICULUS (noun)
  The noun CANALICULUS has 1 sense:

1. a small canal or duct as in some bones and parts of plants

  Familiarity information: CANALICULUS used as a noun is very rare.

 Dictionary entry details 

• CANALICULUS (noun)

Sense 1

Meaning:

A small canal or duct as in some bones and parts of plants

Classified under:

Nouns denoting body parts

Hypernyms ("canaliculus" is a kind of...):

canal; channel; duct; epithelial duct (a bodily passage or tube lined with epithelial cells and conveying a secretion or other substance)

Derivation:

canalicular (relating to or like or having a canaliculus)

 Context examples 

Many canaliculi come together to form bile ductules that ultimately form the common hepatic duct.

(Bile Canaliculus, NCI Thesaurus)

They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.

(Murine Osteocytes, NLM, Medical Subject Headings)

Small vessels between the bile canaliculi and the interlobular bile ducts.

(Canal of Hering, NCI Thesaurus)

Pantoprazole is a lipophilic weak base that crosses the parietal cell membrane and enters the acidic parietal cell canaliculus where it becomes protonated, producing the active metabolite sulphenamide, which forms an irreversible covalent bond with two sites of the H+/K+-ATPase enzyme located on the gastric parietal cell, thereby inhibiting both basal and stimulated gastric acid production.

(Pantoprazole, NCI Thesaurus)

Pantoprazole is a lipophilic, weak base that crosses the parietal cell membrane and enters the acidic parietal cell canaliculus where it becomes protonated, producing the active metabolite sulfenamide, which forms an irreversible covalent bond with two sites of the H+/K+-ATPase enzyme located on the gastric parietal cell, thereby inhibiting both basal and stimulated gastric acid production.

(Pantoprazole Sodium, NCI Thesaurus)

A weak base, ilaprazole accumulates in the acidic environment of the secretory canaliculus of the gastric parietal cell where it is converted to an active sulfenamide form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.

(Ilaprazole, NCI Thesaurus)

As a weak base, dexlansoprazole accumulates in the acidic environment of the secretory canaliculus of the gastric parietal cell where it is converted to an active sulfenamide form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.

(Dexlansoprazole, NCI Thesaurus)

Linaprazan concentrates highly in the gastric parietal cell canaliculus and on entering this acidic environment is instantly protonated and binds competitively and reversibly to the potassium binding site of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.

(Linaprazan, NCI Thesaurus)