ASPARAGINASE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does asparaginase mean? 

• ASPARAGINASE (noun)
  The noun ASPARAGINASE has 1 sense:

1. antineoplastic drug (trade name Elspar) sometimes used to treat lymphoblastic leukemia

  Familiarity information: ASPARAGINASE used as a noun is very rare.

 Dictionary entry details 

• ASPARAGINASE (noun)

Sense 1

Meaning:

Antineoplastic drug (trade name Elspar) sometimes used to treat lymphoblastic leukemia

Classified under:

Nouns denoting man-made objects

Synonyms:

asparaginase; Elspar

Hypernyms ("asparaginase" is a kind of...):

antineoplastic; antineoplastic drug; cancer drug (any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function)

 Context examples 

It is a form of the drug asparaginase that is linked to a substance called PEG, which makes the drug stay in the body longer.

(Oncaspar, NCI Dictionary)

Acinetobacter glutaminase-asparaginase (AGA) possesses both L-glutaminase and L-asparaginase activities, capable of hydrolyzing glutamine and asparagine, thereby disturbing nitrogen supplies for dividing cells.

(Glutaminase-Asparaginase, NCI Thesaurus)

Also called Oncaspar-IV and SC-PEG E. coli L-asparaginase.

(EZN-2285, NCI Dictionary)

Encapsulation of asparaginase in erythrocytes decreases the immunogenicity of exogenous protein, enhances its circulation time and may limit toxicity.

(Erythrocyte-encapsulated L-asparaginase Suspension, NCI Thesaurus)

Also called EZN-2285 and SC-PEG E. coli L-asparaginase.

(Oncaspar-IV, NCI Dictionary)

A pegylated form of glutaminase-asparaginase developed to decrease immunogenicity.

(PEG-Glutaminase-Asparaginase, NCI Thesaurus)

Upon intravenous administration of pegylated recombinant L-asparaginase Erwinia chrysanthemi, asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting cancer cells of asparagine thus blocking protein synthesis and tumor cell proliferation.

(Pegylated Recombinant L-asparaginase Erwinia chrysanthemi, NCI Thesaurus)

Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting these cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle.

(Pegaspargase, NCI Thesaurus)

Mutagenic potential of these non-intercalating DNA topoisomerase II inhibitors is believed to be increased with concurrent use of asparaginase or granulocyte colony-stimulating factor.

(Epipodophyllotoxin-Related Myelodysplastic Syndrome, NCI Thesaurus)

SC is used as a PEG linker to facilitate attachment to asparaginase and enhances the stability of the formulation.

(Calaspargase Pegol, NCI Thesaurus)