English Dictionary

ANAPLASIA

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 Dictionary entry overview: What does anaplasia mean? 

ANAPLASIA (noun)
  The noun ANAPLASIA has 1 sense:

1. loss of structural differentiation within a cell or group of cells often with increased capacity for multiplication, as in a malignant tumorplay

  Familiarity information: ANAPLASIA used as a noun is very rare.


 Dictionary entry details 


ANAPLASIA (noun)


Sense 1

Meaning:

Loss of structural differentiation within a cell or group of cells often with increased capacity for multiplication, as in a malignant tumor

Classified under:

Nouns denoting stable states of affairs

Hypernyms ("anaplasia" is a kind of...):

dysplasia (abnormal development (of organs or cells) or an abnormal structure resulting from such growth)

Derivation:

anaplastic (of or relating to anaplasia)


 Context examples 


When anaplasia is diffuse, it is associated with an unfavorable clinical outcome.

(Anaplastic Renal Wilms Tumor, NCI Thesaurus)

Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis.

(Carcinoma, NCI Thesaurus)

Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia.

(Neoplasm, NCI Thesaurus)

Wilms tumor of the kidney characterized by the absence of nuclear anaplasia.

(Nonanaplastic Renal Wilms Tumor, NCI Thesaurus)

A diffusely infiltrating, WHO grade III astrocytoma with focal or dispersed anaplasia, and a marked proliferative potential.

(Anaplastic Astrocytoma, NCI Thesaurus/WHO)

A malignant neoplasm of the brain or spinal cord originating from astrocytes, exhibiting poor differentiation (anaplasia).

(Anaplastic Astrocytoma, NCI Thesaurus/CDISC)

However, the correlation of histological anaplasia with clinical outcome is inconsistent.

(Anaplastic Ganglioglioma, NCI Thesaurus/Adapted from WHO)

A malignant neoplasm of the central nervous system arising from oligodendrocytes, exhibiting poor differentiation (anaplasia).

(Anaplastic Oligodendroglioma, NCI Thesaurus/CDISC)

A malignant neoplasm of the meninges, exhibiting poor differentiation (anaplasia).

(Anaplastic (Malignant) Meningioma, NCI Thesaurus/CDISC)

Anaplasia is defined by the presence of all of the following: multipolar polyploid mitotic figures, marked nuclear enlargement, and hyperchromasia.

(Anaplastic Renal Wilms Tumor, NCI Thesaurus)



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